There are 8 ways to get from Illinois to Louisville by bus (Greyhound, Flixbus), train, bus, car, subway, plane, or bus (Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Chicago Bus Station to Louisville Bus Stationbus Greyhound US0100
6h 5m$40–90Train, bus via Indianapolis
- Take the train from Chicago Union Station to Indianapolistrain Cardinal
- Take the bus from Indianapolis Union Station to Louisville Bus Stationbus Greyhound US0100 / ...
7h 44m$74–159Drive 293.6 mi
- Drive from Chicago to Louisvillecar 293.6 mi
5h 4m$54–78Subway to Chicago Midway International Airport, fly to Louisville International Airport
- Take the subway from Adams/Wabash to Midwaysubway
- Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane MDW - SDF
3h 56m$88–608Train, bus
- Take the train from Van Buren St. to Gary Metro Centertrain Ssl / ...
- Take the bus from Gary Bus Station to Louisville Bus Stationbus Greyhound US0100
7h 6m$48–88Bus via Lafayette (Amtrak)
- Take the bus from Chicago Union Station to Lafayette Amtrak Stationbus Chicago
- Take the bus from Lafayette Amtrak Station to Louisville, KYbus Chicago
8h 20m$54–94Fly Chicago O'Hare International Airport to Louisville International Airport
- Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane ORD - SDF
4h 25m$68–448Fly Chicago O'Hare International Airport to Blue Grass Airport, drive
- Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane ORD - LEX
- Drive from Lexington-Airport-LEX to Louisvillecar
4h 36m$56–314
Illinois to Louisville by bus
Questions & Answers
The cheapest way to get from Illinois to Louisville is to bus which costs $40 - $90 and takes 6h 5m.
The fastest way to get from Illinois to Louisville is to subway and fly which takes 3h 56m and costs $85 - $650.
Yes, there is a direct bus departing from Chicago Bus Station station and arriving at Louisville Bus Station station. Services depart every four hours, and operate every day. The journey takes approximately 6h 5m.
The distance between Illinois and Louisville is 300 miles. The road distance is 295.3 miles.
The best way to get from Illinois to Louisville without a car is to bus which takes 6h 5m and costs $40 - $90.
The bus from Chicago Bus Station to Louisville Bus Station takes 6h 5m including transfers and departs every four hours.
Illinois to Louisville bus services, operated by Greyhound USA, depart from Chicago Bus Station.
The best way to get from Illinois to Louisville is to bus which takes 6h 5m and costs $40 - $90. Alternatively, you can fly, which costs $65 - $450 and takes 4h 25m.
Illinois to Louisville bus services, operated by Greyhound USA, arrive at Louisville Bus Station.
Louisville is 1h ahead of Illinois. It is currently 8:57 PM in Illinois and 9:57 PM in Louisville.
What companies run services between Illinois, USA and Louisville, KY, USA?
Greyhound USA operates a bus from Chicago Bus Station to Louisville Bus Station 4 times a day. Tickets cost $45–90 and the journey takes 6h 5m. Flixbus USA also services this route twice daily. Alternatively, American Airlines and United Airlines fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF) every 3 hours.
- Website
- southwest.com
Flights from Chicago Midway International Airport to Louisville International Airport
- Ave. Duration
- 1h 16m
- When
- Every day
- Estimated price
- $85–600
Flights from Chicago Midway International Airport to Louisville International Airport via Nashville
- Ave. Duration
- 3h 15m
- When
- Sunday
- Estimated price
- $120–750
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Chicago Union Station to Indianapolis
- Ave. Duration
- 4h 54m
- Frequency
- 3 times a week
- Estimated price
- $50–120
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Chicago Bus Station to Louisville Bus Station
- Ave. Duration
- 6h 5m
- Frequency
- 4 times a day
- Estimated price
- $45–90
- Website
- Greyhound
Bus from Indianapolis Union Station to Louisville Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- 5 times a day
- Estimated price
- $17–35
- Website
- Greyhound
Bus from Gary Bus Station to Louisville Bus Station
- Ave. Duration
- 5h 15m
- Frequency
- Once daily
- Estimated price
- $40–80
- Website
- Greyhound
Want to know more about travelling around United States
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More Questions & Answers
Yes, the driving distance between Illinois to Louisville is 295 miles. It takes approximately 5h 4m to drive from Illinois to Louisville.
Book your Illinois to Louisville bus tickets online with Omio and FlixBus.
There are 628+ hotels available in Louisville.





