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How to get fromIndiana to Knoxvilleby plane, bus (Flixbus), train, bus, or car

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There are 8 ways to get from Indiana to Knoxville by plane, bus (Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Indianapolis

    best
    1. Fly from Indianapolis (IND) to Mcghee Tyson Airport (TYS)plane plane IND - TYS
    5h 38m
    $197–922

  2. Drive  346.8 mi

    cheapest
    1. Drive from Indianapolis to Knoxvillecar car 346.8 mi
    5h 58m
    $64–92

  3. Bus

    1. Take the bus from Indianapolis to New York City Chinatownbus bus FlixBus N2640
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    33h 45m
    $223–299

  4. Train, bus via Farragut

    1. Take the train from Indianapolis to Ny Moynihan Train Hall At Penn Stationtrain train Cardinal
    2. Take the bus from New York to Knoxvillebus bus Nyc
    35h 41m
    $432–798

  5. Train to Chicago O'Hare International Airport, fly

    1. Take the train from Gary to Van Buren St.train train
    2. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    4h 51m
    $175–733

  6. Train to Chicago Midway International Airport, fly

    1. Take the train from Gary to Museum Campus/11th Street Sationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Mcghee Tyson Airport (TYS)plane plane MDW - TYS
    4h 15m
    $214–983

  7. Bus to Nashville, fly

    1. Take the bus from Evansville Bus Station to Nashville Bus Stationbus bus
    2. Fly from Nashville (BNA) to Mcghee Tyson Airport (TYS)plane plane BNA - TYS
    5h 41m
    $181–859

  8. Train, bus

    1. Take the train from Indianapolis to Ny Moynihan Train Hall At Penn Stationtrain train Cardinal
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    35h 45m
    $387–708

Indianapolis (IND) to Mcghee Tyson Airport (TYS) flights

Calendar134Weekly Planes
Duration4h 24mAverage Duration
Ticket$139Cheapest Price
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Questions & Answers

Map of how to get from Indiana to Knoxville.ExpandLaunch map view
  • Distance: 326.5 mi
  • Duration: 5h 38m

What companies run services between Indiana, USA and Knoxville, TN, USA?

Southwest Airlines, Delta, and three other airlines fly from Indianapolis (IND) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Indianapolis to Knoxville Station Hall of Fame via New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 33h 45m.

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