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How to get fromIndiana to Mayo Clinicby train, plane, bus (Flixbus), bus, car, or bus (Amtrak, Greyhound)

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There are 10 ways to get from Indiana to Mayo Clinic by train, plane, bus (Flixbus), bus, car, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Chicago O'Hare International Airport, fly to Rochester

    best
    1. Take the train from Gary to Van Buren St.train train
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    5h 30m
    $56–343

  2. Bus

    1. Take the bus from Indianapolis to Milwaukee Intermodal Stationbus bus FlixBus 2511
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson 966 / ...
    13h 3m
    $114–171

  3. Train, bus

    1. Take the train from Indianapolis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    16h 9m
    $222–439

  4. Drive 526.1 mi

    1. Drive from Indianapolis to Mayo Cliniccar car 526.1 mi
    8h 54m
    $96–139

  5. Fly Indianapolis to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Indianapolis (IND) to Minneapolis–Saint Paul International Airport (MSP)plane plane IND - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 24m
    $554–1,154

  6. Train to Chicago O'Hare International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Gary to Van Buren St.train train
    2. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 13m
    $282–465

  7. Train to Chicago Midway International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Gary to Museum Campus/11th Street Sationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 56m
    $136–545

  8. Train to South Bend, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Gary to South Bend Airporttrain train
    2. Fly from South Bend (SBN) to Minneapolis–Saint Paul International Airport (MSP)plane plane SBN - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 52m
    $147–563

  9. Bus via Chicago

    1. Take the bus from Indianapolis Union Station to Chicago Union Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    13h 46m
    $105–185

  10. Train, bus via Madison

    1. Take the train from Indianapolis to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    15h 6m
    $139–259

Indiana to Mayo Clinic by train, bus, and foot

Calendar3Weekly Services
Duration16h 9mAverage Duration
Ticket$222Cheapest Price
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Questions & Answers

Map of how to get from Indiana to Mayo Clinic.ExpandLaunch map view
  • Distance: 324.9 mi
  • Duration: 5h 30m

What companies run services between Indiana, USA and Mayo Clinic, MN, USA?

You can take a bus from Indianapolis to Mayo Clinic via Milwaukee Intermodal Station, Milwaukee, and Rochester in around 13h 3m.

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