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How to get fromIndianapolis to Cairoby bus, taxi, train, car, or plane

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There are 7 ways to get from Indianapolis to Cairo by bus, taxi, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, taxi

    best
    1. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    3. Take the taxi from Cape Girardeau to Cairotaxi taxi
    7h 52m
    $137–185

  2. Drive  304.3 mi

    cheapest
    1. Drive from Indianapolis to Cairocar car 304.3 mi
    5h 1m
    $56–81

  3. Bus, train, taxi

    1. Take the bus from Indianapolis Union Station to Champaign Intermodal Trans Ctrbus bus
    2. Take the train from Champaign-Urbana to Fulton Amtrak Stationtrain train
    3. Take the taxi from Fulton Amtrak Station to Cairotaxi taxi
    8h 59m
    $204–380

  4. Fly to Barkley Regional Airport, taxi

    1. Fly from Indianapolis (IND) to Barkley Regional Airport (PAH)plane plane IND - PAH
    2. Take the taxi from Barkley Regional Airport (PAH) to Cairotaxi taxi
    7h 36m
    $142–522

  5. Bus, taxi via Nashville (Flixbus)

    1. Take the bus from Indianapolis to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Paducah Bus Stationbus bus
    3. Take the taxi from Paducah Bus Station to Cairotaxi taxi
    11h 10m
    $153–212

  6. Fly to Williamson County Regional Airport, taxi

    1. Fly from Indianapolis (IND) to Williamson County Regional Airport (MWA)plane plane IND - MWA
    2. Take the taxi from Williamson County Regional Airport (MWA) to Cairotaxi taxi
    6h 47m
    $197–632

  7. Fly to Nashville, bus, taxi

    1. Fly from Indianapolis (IND) to Nashville (BNA)plane plane IND - BNA
    2. Take the bus from Nashville Bus Station to Paducah Bus Stationbus bus
    3. Take the taxi from Paducah Bus Station to Cairotaxi taxi
    7h 50m
    $419–1,244

Indianapolis (IND) to Barkley Regional Airport (PAH) flights

Calendar21Weekly Planes
Duration7h 1mAverage Duration
Ticket$75Cheapest Price
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Comparing Your Travel Options

Map of how to get from Indianapolis to Cairo.ExpandLaunch map view
  • Distance: 390.5 mi
  • Duration: 7h 52m

What companies run services between Indianapolis, IN, USA and Cairo, IL, USA?

There is no direct connection from Indianapolis to Cairo. However, you can take the bus to St Louis Bus Station, take the bus to Cape Girardeau, then take the taxi to Cairo. Alternatively, you can take the bus to Champaign Intermodal Trans Ctr, walk to Champaign-Urbana, take the train to Fulton Amtrak Station, then take the taxi to Cairo.

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