Rome2Rio

How to get fromIndianapolis to Florenceby plane, bus (Greyhound), train (Amtrak), or car

Find Transport to Florence

See all options

There are 5 ways to get from Indianapolis to Florence by plane, bus (Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Indianapolis (IND) to Florence Regional Airport (FLO)plane plane IND - FLO
    6h 5m
    $87–445

  2. Bus via Atlanta

    1. Take the bus from Indianapolis to Atlanta Bus Stationbus bus FlixBus 2512
    2. Take the bus from Atlanta to Florencebus bus Ses 987 / ...
    16h 45m

  3. Train (Amtrak)

    1. Take the train from Indianapolis to Alexandriatrain train Cardinal
    2. Take the train from Alexandria to Florence Stationtrain train Palmetto / ...
    26h 41m
    $362–735

  4. Drive 660.6 mi

    1. Drive from Indianapolis to Florencecar car 660.6 mi
    12h 15m
    $121–175

  5. Bus

    1. Take the bus from Indianapolis, IN to Richmond Bsb, INbus bus
    2. Take the bus from Richmond, IN to N Wilson Rd & Ferrell Pl - Columbusbus bus
    3. Take the bus from Columbus to Charlottebus bus
    4. Take the bus from Charlotte Bus Station to Camdenbus bus
    5. Take the bus from Camden to Florencebus bus
    19h 50m

Indianapolis (IND) to Florence Regional Airport (FLO) flights

Calendar14Weekly Planes
Duration4h 15mAverage Duration
Ticket$79Cheapest Price
See schedules

Questions & Answers

Map of how to get from Indianapolis to Florence.ExpandLaunch map view
  • Distance: 544.2 mi
  • Duration: 6h 5m

What companies run services between Indianapolis, IN, USA and Florence, SC, USA?

American Airlines flies from Indianapolis (IND) to Florence Regional Airport (FLO) twice daily. Alternatively, you can take a bus from Indianapolis to Florence via Atlanta in around 16h 45m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers