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How to get fromIndianapolis to Kirksvilleby bus, train, train (Amtrak), car, or plane

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There are 8 ways to get from Indianapolis to Kirksville by bus, train, train (Amtrak), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train via Galesburg

    best
    1. Take the bus from Indianapolis Union Station to Galesburgbus bus Greyhound US0157S
    2. Take the train from Galesburg Amtrak Station to La Plata Stationtrain train Southwest Chief
    8h 25m
    $124–219

  2. Drive 389.6 mi

    cheapest
    1. Drive from Indianapolis to Kirksvillecar car 389.6 mi
    7h 9m
    $72–103

  3. Train (Amtrak)

    1. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to La Plata Stationtrain train Southwest Chief
    11h 9m
    $204–384

  4. Bus to Chicago O'Hare International Airport, fly to Kirksville Regional Airport

    1. Take the bus from Indianapolis to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Kirksville Regional Airport (IRK)plane plane ORD - IRK
    7h 25m
    $132–290

  5. Bus, train

    1. Take the bus from Indianapolis to Galesburgbus bus Btw 1401
    2. Take the train from Galesburg Amtrak Station to La Plata Stationtrain train Southwest Chief
    8h 40m

  6. Fly Indianapolis to Kirksville Regional Airport

    1. Fly from Indianapolis (IND) to Kirksville Regional Airport (IRK)plane plane IND - IRK
    6h 34m
    $167–647

  7. Fly Indianapolis to Kansas City, train

    1. Fly from Indianapolis (IND) to Kansas City (MCI)plane plane IND - MCI
    2. Take the train from Kansas City to La Plata Stationtrain train
    8h 50m
    $742–1,152

  8. Train to Purdue University Airport, fly to Kirksville Regional Airport

    1. Take the train from Indianapolis to Lafayette Amtrak Stationtrain train
    2. Fly from Purdue University Airport (LAF) to Kirksville Regional Airport (IRK)plane plane LAF - IRK
    15h 8m
    $181–576

Chicago O'Hare International Airport (ORD) to Kirksville Regional Airport (IRK) flights

Calendar7Weekly Planes
Duration1h 30mAverage Duration
Ticket$68Cheapest Price
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Questions & Answers

Map of how to get from Indianapolis to Kirksville.ExpandLaunch map view
  • Distance: 404 mi
  • Duration: 8h 25m

What companies run services between Indianapolis, IN, USA and Kirksville, MO, USA?

You can take a train from Indianapolis to Kirksville via Chicago Union Station and La Plata Station in around 11h 9m. Alternatively, United Airlines, Corporate Flight Management Inc, and two other airlines fly from Indianapolis (IND) to Kirksville Regional Airport (IRK) 3 times a day.

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