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How to get fromIndianapolis to Knoxvilleby plane, bus, train, or car

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There are 6 ways to get from Indianapolis to Knoxville by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Indianapolis (IND) to Mcghee Tyson Airport (TYS)plane plane IND - TYS
    5h 13m
    $177–822

  2. Drive 346.8 mi

    cheapest
    1. Drive from Indianapolis to Knoxvillecar car 346.8 mi
    5h 58m
    $64–92

  3. Bus

    1. Take the bus from Indianapolis to New York City Chinatownbus bus FlixBus N2640
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    33h 45m
    $278–360

  4. Train, bus via Farragut

    1. Take the train from Indianapolis to Ny Moynihan Train Hall At Penn Stationtrain train Cardinal
    2. Take the bus from New York to Knoxvillebus bus Nyc
    35h 41m
    $490–867

  5. Fly to Nashville, drive

    1. Fly from Indianapolis (IND) to Nashville (BNA)plane plane IND - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    5h 45m
    $342–1,152

  6. Train, bus

    1. Take the train from Indianapolis to Ny Moynihan Train Hall At Penn Stationtrain train Cardinal
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    35h 45m
    $445–777

Indianapolis (IND) to Mcghee Tyson Airport (TYS) flights

Calendar143Weekly Planes
Duration4h 42mAverage Duration
Ticket$125Cheapest Price
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Questions & Answers

Map of how to get from Indianapolis to Knoxville.ExpandLaunch map view
  • Distance: 326.5 mi
  • Duration: 5h 13m

What companies run services between Indianapolis, IN, USA and Knoxville, TN, USA?

Southwest Airlines, Delta, and two other airlines fly from Indianapolis (IND) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Indianapolis to Knoxville Station Hall of Fame via New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 33h 45m.

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