There are 6 ways to get from Indianapolis to La Crosse by plane, train (Amtrak), bus (Flixbus, Greyhound), car, bus, train, or bus (Amtrak, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Indianapolis
best- Fly from Indianapolis (IND) to La Crosse (LSE)plane IND - LSE
6h 3m$86–435Drive 461 mi
cheapest- Drive from Indianapolis to La Crossecar 461 mi
7h 51m$85–122Train (Amtrak)
- Take the train from Indianapolis to Chicago Union Stationtrain Cardinal
- Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain Empire Builder / ...
10h 59m$129–336Bus via Milwaukee
- Take the bus from Indianapolis to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus
- Take the bus from Milwaukee to La Crossebus
11h$91–139Bus, train to Chicago O'Hare International Airport, fly
- Take the bus from Indianapolis to Gary Bus Stationbus
- Take the train from Gary to Van Buren St.train
- Fly from Chicago O'Hare International Airport (ORD) to La Crosse (LSE)plane ORD - LSE
7h 35m$87–333Bus
- Take the bus from Indianapolis Union Station to Chicago Union Stationbus
- Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus
- Take the bus from Madison to La Crossebus
11h 17m$90–156
Indianapolis to La Crosse by train (Amtrak)
Comparing Your Travel Options
The cheapest way to get from Indianapolis to La Crosse is to drive which costs $80 - $130 and takes 7h 51m.
The fastest way to get from Indianapolis to La Crosse is to fly which takes 6h 3m and costs $85 - $440.
No, there is no direct bus from Indianapolis to La Crosse. However, there are services departing from Indianapolis and arriving at La Crosse via Chicago Bus Station and Milwaukee. The journey, including transfers, takes approximately 11h.
No, there is no direct train from Indianapolis to La Crosse station. However, there are services departing from Indianapolis and arriving at La Crosse Amtrak Station via Chicago Union Station. The journey, including transfers, takes approximately 10h 59m.
The distance between Indianapolis and La Crosse is 410 miles. The road distance is 463.7 miles.
The best way to get from Indianapolis to La Crosse without a car is to train which takes 10h 59m and costs $120 - $340.
It takes approximately 6h 3m to get from Indianapolis to La Crosse, including transfers.
Indianapolis to La Crosse bus services, operated by Flixbus USA, depart from Indianapolis station.
Indianapolis to La Crosse train services, operated by Amtrak, depart from Indianapolis station.
The best way to get from Indianapolis to La Crosse is to fly which takes 6h 3m and costs $85 - $440. Alternatively, you can train, which costs $120 - $340 and takes 10h 59m, you could also bus via Milwaukee, which costs $90 - $140 and takes 11h.
What companies run services between Indianapolis, IN, USA and La Crosse, WI, USA?
American Airlines and United Airlines fly from Indianapolis (IND) to La Crosse (LSE) 5 times a day. Alternatively, you can take a train from Indianapolis to La Crosse Amtrak Station via Chicago Union Station in around 10h 59m.
- Website
- aa.com
Flights from Indianapolis to La Crosse via Chicago O'Hare International Airport
- Ave. Duration
- 4h 51m
- When
- Every day
- Estimated price
- $65–410
Flights from Chicago O'Hare International Airport to La Crosse
- Ave. Duration
- 1h 24m
- When
- Every day
- Estimated price
- $35–260
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Indianapolis to Chicago Union Station
- Ave. Duration
- 5h
- Frequency
- 3 times a week
- Estimated price
- $50–140
- Website
- Amtrak
Train from Chicago Union Station to La Crosse Amtrak Station
- Ave. Duration
- 4h 59m
- Frequency
- 3 times a day
- Estimated price
- $75–200
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Indianapolis to Chicago Bus Station
- Ave. Duration
- 3h 40m
- Frequency
- Every 4 hours
- Estimated price
- $27–45
- Schedules at
- Flixbus USA
Bus from Chicago Bus Station to Milwaukee Intermodal Station
- Ave. Duration
- 1h 55m
- Frequency
- 3 times a day
- Estimated price
- $13–20
- Schedules at
- Flixbus USA
Bus from Indianapolis to Gary Bus Station
- Ave. Duration
- 2h 55m
- Frequency
- 5 times a week
- Estimated price
- $23–35
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
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Booking & Getting There
Indianapolis to La Crosse bus services, operated by Flixbus USA, arrive at Chicago Bus Station.
La Crosse is 1h behind Indianapolis. It is currently 4:34 PM in Indianapolis and 3:34 PM in La Crosse.
Indianapolis to La Crosse train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Indianapolis to La Crosse is 464 miles. It takes approximately 7h 51m to drive from Indianapolis to La Crosse.
Book your Indianapolis to La Crosse train tickets online with Omio.
Book your Indianapolis to La Crosse bus tickets online with Omio.
There are 47+ hotels available in La Crosse.