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How to get fromIndianapolis to La Crosseby plane, bus, train, bus (Flixbus, Greyhound), car, train (Amtrak), or bus (Greyhound)

Find Transport to La Crosse

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There are 7 ways to get from Indianapolis to La Crosse by plane, bus, train, bus (Flixbus, Greyhound), car, train (Amtrak), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Indianapolis

    best
    1. Fly from Indianapolis (IND) to La Crosse (LSE)plane plane IND - LSE
    5h 45m
    $86–445

  2. Drive  461 mi

    cheapest
    1. Drive from Indianapolis to La Crossecar car 461 mi
    7h 51m
    $79–114

  3. Bus, train

    1. Take the bus from Indianapolis to Chicago Bus Stationbus bus FlixBus 2511 / ...
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    9h 48m
    $179–283

  4. Bus via Milwaukee

    1. Take the bus from Indianapolis to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to La Crossebus bus
    10h 54m
    $93–143

  5. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Indianapolis to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to La Crosse (LSE)plane plane ORD - LSE
    7h 16m
    $88–324

  6. Train (Amtrak)

    1. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    10h 59m
    $257–405

  7. Bus

    1. Take the bus from Indianapolis Union Station to Chicago Bus Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to La Crossebus bus
    11h 20m
    $94–160

Indianapolis to La Crosse by bus, foot, and train

Calendar21Weekly Services
Duration9h 48mAverage Duration
Ticket$179Cheapest Price
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Comparing Your Travel Options

Map of how to get from Indianapolis to La Crosse.ExpandLaunch map view
  • Distance: 406.3 mi
  • Duration: 5h 45m

What companies run services between Indianapolis, IN, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from Indianapolis (IND) to La Crosse (LSE) every 4 hours. Alternatively, you can take a bus from Indianapolis to La Crosse via Chicago Bus Station, Milwaukee Intermodal Station, and Milwaukee in around 10h 54m.

Airlines
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Bus operators

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