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How to get fromIndianapolis to La Crosseby plane, bus, train (Amtrak), car, train, or bus (Greyhound)

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There are 7 ways to get from Indianapolis to La Crosse by plane, bus, train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Indianapolis

    best
    1. Fly from Indianapolis (IND) to La Crosse (LSE)plane plane IND - LSE
    5h 58m
    $86–425

  2. Drive 461 mi

    cheapest
    1. Drive from Indianapolis to La Crossecar car 461 mi
    7h 51m
    $85–122

  3. Bus

    1. Take the bus from Indianapolis to Madisonbus bus FlixBus 2514
    2. Take the bus from Madison to La Crossebus bus Jefferson 966 / ...
    10h 40m

  4. Train (Amtrak)

    1. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    10h 59m
    $154–318

  5. Train to Purdue University Airport, fly

    1. Take the train from Indianapolis to Lafayette Amtrak Stationtrain train
    2. Fly from Purdue University Airport (LAF) to La Crosse (LSE)plane plane LAF - LSE
    7h 58m
    $94–383

  6. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Indianapolis to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to La Crosse (LSE)plane plane ORD - LSE
    7h 18m
    $91–356

  7. Bus via Chicago

    1. Take the bus from Indianapolis Union Station to Chicago Bus Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to La Crossebus bus
    11h 24m
    $89–165

Indianapolis to La Crosse by train (Amtrak)

Calendar3Weekly Trains
Duration10h 59mAverage Duration
Ticket$154Cheapest Price
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Questions & Answers

Map of how to get from Indianapolis to La Crosse.ExpandLaunch map view
  • Distance: 407.8 mi
  • Duration: 5h 58m

What companies run services between Indianapolis, IN, USA and La Crosse, WI, USA?

United Airlines, American Airlines, and Allegiant Air fly from Indianapolis (IND) to La Crosse (LSE) every 4 hours. Alternatively, you can take a bus from Indianapolis to La Crosse via Madison in around 10h 40m.

Airlines
Train operators
Bus operators

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