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How to get fromIndianapolis to Lake Cityby plane, bus, bus (Greyhound, Amtrak), car, or bus (Flixbus, Greyhound)

Find Transport to Lake City

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There are 8 ways to get from Indianapolis to Lake City by plane, bus, bus (Greyhound, Amtrak), car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Jacksonville, bus

    best
    1. Fly from Indianapolis (IND) to Jacksonville (JAX)plane plane IND - JAX
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    7h 28m
    $112–570

  2. Fly to Gainesville Regional Airport, bus

    cheapest
    1. Fly from Indianapolis (IND) to Gainesville Regional Airport (GNV)plane plane IND - GNV
    2. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    10h 1m
    $102–507

  3. Bus

    1. Take the bus from Indianapolis Union Station to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Lake City Bus Stationbus bus
    18h 45m
    $141–201

  4. Drive  772.7 mi

    1. Drive from Indianapolis to Lake Citycar car 772.7 mi
    14h 4m
    $141–204

  5. Fly to Orlando Sanford, drive

    1. Fly from Indianapolis (IND) to Orlando Sanford (SFB)plane plane IND - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Lake Citycar car
    6h 57m
    $125–547

  6. Fly to Orlando, bus

    1. Fly from Indianapolis (IND) to Orlando (MCO)plane plane IND - MCO
    2. Take the bus from Orlando Bus Station to Lake City Bus Stationbus bus
    10h 16m
    $180–796

  7. Fly to Valdosta, bus

    1. Fly from Indianapolis (IND) to Valdosta (VLD)plane plane IND - VLD
    2. Take the bus from Valdosta to Gainesville Bus Stopbus bus
    3. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    10h 25m
    $121–525

  8. Bus via Atlanta

    1. Take the bus from Indianapolis to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Gainesvillebus bus
    3. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    20h 40m
    $138–214

Indianapolis to Lake City by bus

Calendar7Weekly Buses
Duration18h 45mAverage Duration
Ticket$141Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Indianapolis to Lake City.ExpandLaunch map view
  • Distance: 782.1 mi
  • Duration: 7h 28m

What companies run services between Indianapolis, IN, USA and Lake City, FL, USA?

You can take a bus from Indianapolis Union Station to Lake City Bus Station via Nashville Bus Station and Tallahassee in around 18h 45m.

Airlines
Bus operators

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Need to know: Greyhound

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