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How to get fromIndianapolis to Mayo Clinicby plane, bus, train, car, or bus (Greyhound)

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There are 9 ways to get from Indianapolis to Mayo Clinic by plane, bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Indianapolis to Rochester

    best
    1. Fly from Indianapolis (IND) to Rochester (RST)plane plane IND - RST
    6h 58m
    $72–412

  2. Bus

    1. Take the bus from Indianapolis to Madisonbus bus FlixBus 2514
    2. Take the bus from Madison to Rochesterbus bus Jefferson 966 / ...
    12h 48m

  3. Train, bus

    1. Take the train from Indianapolis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    16h 9m
    $222–438

  4. Drive 526.1 mi

    1. Drive from Indianapolis to Mayo Cliniccar car 526.1 mi
    8h 54m
    $96–139

  5. Fly Indianapolis to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Indianapolis (IND) to Minneapolis–Saint Paul International Airport (MSP)plane plane IND - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 24m
    $554–1,154

  6. Train to Purdue University Airport, fly to Rochester

    1. Take the train from Indianapolis to Lafayette Amtrak Stationtrain train
    2. Fly from Purdue University Airport (LAF) to Rochester (RST)plane plane LAF - RST
    9h 46m
    $75–370

  7. Bus to Chicago O'Hare International Airport, fly to Rochester

    1. Take the bus from Indianapolis to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    8h 30m
    $77–343

  8. Bus via Chicago

    1. Take the bus from Indianapolis Union Station to Chicago Bus Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    13h 32m
    $104–185

  9. Train, bus via Madison

    1. Take the train from Indianapolis to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    14h 44m
    $139–258

Indianapolis to Mayo Clinic by train, bus, and foot

Calendar3Weekly Services
Duration16h 9mAverage Duration
Ticket$222Cheapest Price
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Questions & Answers

Map of how to get from Indianapolis to Mayo Clinic.ExpandLaunch map view
  • Distance: 455.9 mi
  • Duration: 6h 58m

What companies run services between Indianapolis, IN, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and United Airlines fly from Indianapolis (IND) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Indianapolis to Mayo Clinic via Madison and Rochester in around 12h 48m.

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