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How to get fromIndianapolis to Mayo Clinicby plane, bus (Flixbus), train, bus, car, or bus (Amtrak, Greyhound)

Find Transport to Mayo Clinic

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There are 7 ways to get from Indianapolis to Mayo Clinic by plane, bus (Flixbus), train, bus, car, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Indianapolis (IND) to Rochester (RST)plane plane IND - RST
    7h
    $73–462

  2. Bus

    1. Take the bus from Indianapolis to Madisonbus bus FlixBus 2514
    2. Take the bus from Madison to Rochesterbus bus Jefferson Lines 966
    12h 48m
    $100–150

  3. Train, bus

    1. Take the train from Indianapolis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    16h 4m
    $192–466

  4. Drive  526.1 mi

    1. Drive from Indianapolis to Mayo Cliniccar car 526.1 mi
    8h 54m
    $96–139

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Indianapolis (IND) to Minneapolis–Saint Paul International Airport (MSP)plane plane IND - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 27m
    $554–1,054

  6. Bus via Chicago

    1. Take the bus from Indianapolis Union Station to Chicago Union Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    13h 26m
    $105–176

  7. Train, bus via Madison

    1. Take the train from Indianapolis to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    14h 46m
    $129–266

Indianapolis to Mayo Clinic by bus and foot

Calendar6Weekly Services
Duration12h 48mAverage Duration
Ticket$100Cheapest Price
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Comparing Your Travel Options

Map of how to get from Indianapolis to Mayo Clinic.ExpandLaunch map view
  • Distance: 455.9 mi
  • Duration: 7h

What companies run services between Indianapolis, IN, USA and Mayo Clinic, MN, USA?

Delta and American Airlines fly from Indianapolis (IND) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Indianapolis to Mayo Clinic via Madison and Rochester in around 12h 48m.

Airlines
Train operators
Bus operators

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