There are 10 ways to get from Indianapolis to Orangeburg by plane, taxi, bus (Greyhound, Flixbus), train, bus, car, or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Indianapolis to Columbia, taxi
best- Fly from Indianapolis (IND) to Columbia (CAE)plane IND - CAE
- Take the taxi from Columbia-Airport-CAE to Orangeburgtaxi
6h 11m$197–592Fly Indianapolis to Augusta Regional Airport At Bush Field, drive
cheapest- Fly from Indianapolis (IND) to Augusta Regional Airport At Bush Field (AGS)plane IND - AGS
- Drive from Augusta Regional Airport At Bush Field (AGS) to Orangeburgcar
7h 22m$91–473Bus
- Take the bus from Indianapolis Union Station to Wilson & Ferrell Shell Station - Columbusbus
- Take the bus from Columbus to Charlottebus
- Take the bus from Charlotte Bus Station to Orangeburgbus
19h 23m$101–189Train, bus
- Take the train from Indianapolis to Charlottesvilletrain
- Take the train from Charlottesville to Charlotte Amtrak Stationtrain
- Take the bus from Charlotte Bus Station to Orangeburgbus
26h 7m$269–663Drive 621.2 mi
- Drive from Indianapolis to Orangeburgcar 621.2 mi
11h 35m$114–164Fly Indianapolis to Charleston International Airport, drive
- Fly from Indianapolis (IND) to Charleston International Airport (CHS)plane IND - CHS
- Drive from Charleston-Airport-CHS to Orangeburgcar
6h 43m$109–571Fly Indianapolis to Savannah, train
- Fly from Indianapolis (IND) to Savannah (SAV)plane IND - SAV
- Take the train from Savannah Station to Denmark Amtrak Stationtrain
6h 41m$261–947Bus to Covington, fly to Charleston International Airport, drive
- Take the bus from Indianapolis to Cincinnatibus
- Fly from Covington (CVG) to Charleston International Airport (CHS)plane CVG - CHS
- Drive from Charleston-Airport-CHS to Orangeburgcar
7h 11m$131–699Fly Indianapolis to Charlotte Douglas International Airport, bus
- Fly from Indianapolis (IND) to Charlotte Douglas International Airport (CLT)plane IND - CLT
- Take the bus from Charlotte Bus Station to Orangeburgbus
7h 52m$134–703Bus via Atlanta
- Take the bus from Indianapolis to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Charlotte Bus Stationbus
- Take the bus from Charlotte Bus Station to Orangeburgbus
20h 3m$148–237
Indianapolis (IND) to Columbia (CAE) flights
Comparing Your Travel Options
The cheapest way to get from Indianapolis to Orangeburg is to drive which costs $110 - $170 and takes 11h 35m.
The fastest way to get from Indianapolis to Orangeburg is to fly and taxi which takes 6h 11m and costs $190 - $600.
No, there is no direct bus from Indianapolis station to Orangeburg. However, there are services departing from Indianapolis Union Station and arriving at Orangeburg via Columbus and Charlotte Bus Station. The journey, including transfers, takes approximately 19h 23m.
The distance between Indianapolis and Orangeburg is 549 miles. The road distance is 624.9 miles.
The best way to get from Indianapolis to Orangeburg without a car is to bus which takes 19h 23m and costs $100 - $190.
It takes approximately 6h 11m to get from Indianapolis to Orangeburg, including transfers.
Indianapolis to Orangeburg bus services, operated by Greyhound USA, depart from Indianapolis Union Station.
Indianapolis to Orangeburg bus services, operated by Greyhound USA, arrive at Wilson & Ferrell Shell Station - Columbus.
Yes, the driving distance between Indianapolis to Orangeburg is 625 miles. It takes approximately 11h 35m to drive from Indianapolis to Orangeburg.
Book your Indianapolis to Orangeburg bus tickets online with Omio.
What companies run services between Indianapolis, IN, USA and Orangeburg, SC, USA?
You can take a bus from Indianapolis Union Station to Orangeburg via Columbus, Charlotte Bus Station, and Orangeburg in around 19h 23m.
- Website
- aa.com
Flights from Indianapolis to Columbia via Charlotte Douglas International Airport
- Ave. Duration
- 4h 11m
- When
- Every day
- Estimated price
- $75–440
Flights from Indianapolis to Columbia via Chicago O'Hare
- Ave. Duration
- 5h 17m
- When
- Every day
- Estimated price
- $95–550
Flights from Indianapolis to Columbia via New York La Guardia
- Ave. Duration
- 6h 3m
- When
- Every day
- Estimated price
- $130–650
Flights from Indianapolis to Columbia via Reagan Washington
- Ave. Duration
- 6h 4m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–550
Flights from Indianapolis to Columbia via Philadelphia
- Ave. Duration
- 6h 20m
- When
- Every day
- Estimated price
- $110–600
Flights from Indianapolis to Charleston International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 23m
- When
- Every day
- Estimated price
- $95–550
Flights from Indianapolis to Charleston International Airport via Reagan Washington
- Ave. Duration
- 4h 56m
- When
- Every day
- Estimated price
- $120–650
Flights from Indianapolis to Augusta Regional Airport At Bush Field via Charlotte Douglas International Airport
- Ave. Duration
- 4h 43m
- When
- Every day
- Estimated price
- $75–450
Flights from Indianapolis to Augusta Regional Airport At Bush Field via Chicago O'Hare
- Ave. Duration
- 4h 24m
- When
- Sunday
- Estimated price
- $100–550
Flights from Indianapolis to Augusta Regional Airport At Bush Field via Reagan Washington
- Ave. Duration
- 6h 34m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–550
Flights from Indianapolis to Savannah via Charlotte Douglas International Airport
- Ave. Duration
- 4h 7m
- When
- Every day
- Estimated price
- $130–750
Flights from Covington to Charleston International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 11m
- When
- Every day
- Estimated price
- $100–650
Flights from Indianapolis to Charlotte Douglas International Airport
- Ave. Duration
- 1h 46m
- When
- Every day
- Estimated price
- $100–650
- Website
- delta.com
Flights from Indianapolis to Columbia via Atlanta
- Ave. Duration
- 4h 19m
- When
- Every day
- Estimated price
- $80–470
Flights from Indianapolis to Columbia via New York La Guardia
- Ave. Duration
- 7h 13m
- When
- Every day
- Estimated price
- $130–650
Flights from Indianapolis to Charleston International Airport via Atlanta
- Ave. Duration
- 4h 21m
- When
- Every day
- Estimated price
- $100–600
Flights from Indianapolis to Charleston International Airport via Detroit
- Ave. Duration
- 5h 6m
- When
- Every day
- Estimated price
- $120–650
Flights from Indianapolis to Augusta Regional Airport At Bush Field via Atlanta
- Ave. Duration
- 4h 9m
- When
- Every day
- Estimated price
- $80–450
Flights from Indianapolis to Savannah via Atlanta
- Ave. Duration
- 4h 3m
- When
- Every day
- Estimated price
- $130–750
Flights from Covington to Charleston International Airport via Atlanta
- Ave. Duration
- 4h
- When
- Every day
- Estimated price
- $120–700
Flights from Indianapolis to Charlotte Douglas International Airport via Atlanta
- Ave. Duration
- 3h 46m
- When
- Every day
- Estimated price
- $120–700
Flights from Indianapolis to Charlotte Douglas International Airport via Detroit
- Ave. Duration
- 4h 1m
- When
- Every day
- Estimated price
- $130–750
- Website
- southwest.com
Flights from Indianapolis to Charleston International Airport via Nashville
- Ave. Duration
- 3h 50m
- When
- Tuesday, Wednesday, and Saturday
- Estimated price
- $100–600
Flights from Indianapolis to Charleston International Airport via Baltimore
- Ave. Duration
- 4h 47m
- When
- Every day
- Estimated price
- $130–700
Flights from Indianapolis to Charleston International Airport via Chicago Midway
- Ave. Duration
- 4h 52m
- When
- Saturday and Sunday
- Estimated price
- $120–650
Flights from Indianapolis to Savannah via Nashville
- Ave. Duration
- 3h 55m
- When
- Tuesday, Wednesday, and Sunday
- Estimated price
- $130–800
Flights from Indianapolis to Savannah via Chicago Midway
- Ave. Duration
- 4h 20m
- When
- Tuesday and Wednesday
- Estimated price
- $160–900
Flights from Covington to Charleston International Airport via Nashville
- Ave. Duration
- 3h 40m
- When
- Saturday
- Estimated price
- $120–700
Flights from Indianapolis to Charlotte Douglas International Airport via Nashville
- Ave. Duration
- 3h 21m
- When
- Saturday, Sunday, Monday, Thursday, and Friday
- Estimated price
- $110–700
Flights from Indianapolis to Charlotte Douglas International Airport via Chicago Midway
- Ave. Duration
- 3h 50m
- When
- Monday, Thursday, Friday, and Saturday
- Estimated price
- $130–750
- Website
- united.com
Flights from Indianapolis to Columbia via Washington Dulles
- Ave. Duration
- 4h 31m
- When
- Every day
- Estimated price
- $100–550
Flights from Indianapolis to Columbia via Newark
- Ave. Duration
- 5h 10m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $120–650
Flights from Indianapolis to Columbia via Chicago O'Hare
- Ave. Duration
- 5h 43m
- When
- Every day
- Estimated price
- $95–550
Flights from Indianapolis to Charleston International Airport via Washington Dulles
- Ave. Duration
- 4h 52m
- When
- Every day
- Estimated price
- $120–650
- Website
- allegiantair.com
Flights from Indianapolis to Savannah
- Ave. Duration
- 1h 46m
- When
- Monday and Friday
- Estimated price
- $130–750
Flights from Covington to Charleston International Airport
- Ave. Duration
- 1h 38m
- When
- Thursday and Sunday
- Estimated price
- $100–650
- Website
- flybreeze.com
Flights from Covington to Charleston International Airport
- Ave. Duration
- 1h 39m
- When
- Tuesday, Thursday, and Sunday
- Estimated price
- $230–1,500
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Indianapolis to Charlottesville
- Ave. Duration
- 15h 20m
- Frequency
- 3 times a week
- Estimated price
- $160–430
- Website
- Amtrak
Train from Charlottesville to Charlotte Amtrak Station
- Ave. Duration
- 5h 38m
- Frequency
- Once daily
- Estimated price
- $70–190
- Website
- Amtrak
Train from Savannah Station to Denmark Amtrak Station
- Ave. Duration
- 1h 21m
- Frequency
- Once daily
- Estimated price
- $24–65
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Indianapolis Union Station to Wilson & Ferrell Shell Station - Columbus
- Ave. Duration
- 4h 25m
- Frequency
- 3 times a day
- Estimated price
- $28–45
- Website
- Greyhound
Bus from Charlotte Bus Station to Orangeburg
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $22–35
- Website
- Greyhound
Bus from Charlotte Bus Station to Orangeburg
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $22–35
- Website
- Greyhound
Bus from Charlotte Bus Station to Orangeburg
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $22–35
- Website
- Greyhound
Bus from Atlanta Bus Station to Charlotte Bus Station
- Ave. Duration
- 4h 20m
- Frequency
- Every 4 hours
- Estimated price
- $35–65
- Website
- Greyhound
Bus from Charlotte Bus Station to Orangeburg
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $22–35
- Website
- Greyhound
- Phone
- +1 888-378-3823
- [email protected]
- Website
- Barons Bus
Bus from Columbus to Charlotte
- Ave. Duration
- 10h 20m
- Frequency
- Once daily
- Estimated price
- $45–100
- Website
- Barons Bus
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Charlotte Bus Station to Orangeburg
- Ave. Duration
- 2h 35m
- Frequency
- Once daily
- Estimated price
- $20–35
- Schedules at
- Flixbus USA
Bus from Charlotte Bus Station to Orangeburg
- Ave. Duration
- 2h 35m
- Frequency
- Once daily
- Estimated price
- $20–35
- Schedules at
- Flixbus USA
Bus from Indianapolis to Cincinnati
- Ave. Duration
- 2h
- Frequency
- Twice daily
- Estimated price
- $16–26
- Schedules at
- Flixbus USA
Bus from Charlotte Bus Station to Orangeburg
- Ave. Duration
- 2h 35m
- Frequency
- Once daily
- Estimated price
- $20–35
- Schedules at
- Flixbus USA
Bus from Indianapolis to Atlanta Bus Station
- Ave. Duration
- 11h 5m
- Frequency
- Twice daily
- Estimated price
- $85–130
- Schedules at
- Flixbus USA
Bus from Atlanta Bus Station to Charlotte Bus Station
- Ave. Duration
- 4h 25m
- Frequency
- 3 times a day
- Estimated price
- $35–55
- Schedules at
- Flixbus USA
Bus from Charlotte Bus Station to Orangeburg
- Ave. Duration
- 2h 35m
- Frequency
- Once daily
- Estimated price
- $20–35
- Schedules at
- Flixbus USA
- Ave. Duration
- 42 min
- Estimated price
- $120–150
Checker Yellow Cabs
- Phone
- +1 803-799-3311
- Website
- checkeryellowcab.com
Want to know more about travelling around United States
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Booking & Getting There
There are 22+ hotels available in Orangeburg.










