There are 4 ways to get from Indianapolis to Saint Charles by bus (Greyhound), car, plane, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus (Greyhound)
best- Take the bus from Indianapolis Union Station to St Louis Bus Stationbus Greyhound US0421
5h 20m$44–78Drive 255.9 mi
- Drive from Indianapolis to Saint Charlescar 255.9 mi
4h 19m$47–68Fly from Indianapolis
- Fly from Indianapolis (IND) to Lambert–St. Louis International Airport (STL)plane IND - STL
6h 3m$106–606Train to Purdue University Airport, fly
- Take the train from Indianapolis to Lafayette Amtrak Stationtrain
- Fly from Purdue University Airport (LAF) to Lambert–St. Louis International Airport (STL)plane LAF - STL
8h 32m$104–514
Indianapolis to Saint Charles by bus and train (Greyhound)
Questions & Answers
The cheapest way to get from Indianapolis to Saint Charles is to bus which costs $40 - $80 and takes 5h 20m.
The fastest way to get from Indianapolis to Saint Charles is to drive which takes 4h 19m and costs $45 - $70.
No, there is no direct bus from Indianapolis station to Saint Charles. However, there are services departing from Indianapolis Union Station and arriving at 4375 Rider Trail North Sb via North Hanley Transit Center. The journey, including transfers, takes approximately 5h 20m.
The distance between Indianapolis and Saint Charles is 265 miles. The road distance is 257.4 miles.
The best way to get from Indianapolis to Saint Charles without a car is to bus which takes 5h 20m and costs $40 - $80.
It takes approximately 5h 20m to get from Indianapolis to Saint Charles, including transfers.
Indianapolis to Saint Charles bus services, operated by Greyhound USA, depart from Indianapolis Union Station.
The best way to get from Indianapolis to Saint Charles is to bus which takes 5h 20m and costs $40 - $80. Alternatively, you can fly, which costs $100 - $650 and takes 6h 3m.
Indianapolis to Saint Charles bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Saint Charles is 1h behind Indianapolis. It is currently 3:32 AM in Indianapolis and 2:32 AM in Saint Charles.
What companies run services between Indianapolis, IN, USA and Saint Charles, MO, USA?
Greyhound USA operates a bus from Indianapolis Union Station to St Louis Bus Station 3 times a day. Tickets cost $40–75 and the journey takes 3h 55m. Alternatively, Southwest Airlines, Delta, and two other airlines fly from Indianapolis (IND) to Lambert–St. Louis International Airport (STL) hourly.
- Website
- delta.com
Flights from Indianapolis to Lambert–St. Louis International Airport via Detroit
- Ave. Duration
- 3h 55m
- When
- Every day
- Estimated price
- $130–700
Flights from Indianapolis to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 4h 49m
- When
- Every day
- Estimated price
- $160–800
Flights from Indianapolis to Lambert–St. Louis International Airport via Minneapolis
- Ave. Duration
- 4h 23m
- When
- Every day
- Estimated price
- $160–800
- Website
- united.com
Flights from Indianapolis to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- $100–600
Flights from Purdue University Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 4h 11m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $75–460
- Website
- southwest.com
Flights from Indianapolis to Lambert–St. Louis International Airport via Chicago Midway
- Ave. Duration
- 3h 57m
- When
- Sunday, Monday, Thursday, and Friday
- Estimated price
- $100–600
Flights from Indianapolis to Lambert–St. Louis International Airport via Nashville
- Ave. Duration
- 3h 50m
- When
- Sunday
- Estimated price
- $110–650
Flights from Indianapolis to Lambert–St. Louis International Airport via Kansas City
- Ave. Duration
- 3h 42m
- When
- Saturday, Monday, Thursday, and Friday
- Estimated price
- $130–700
- Website
- aa.com
Flights from Indianapolis to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- $100–600
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Indianapolis to Lafayette Amtrak Station
- Ave. Duration
- 1h 36m
- Frequency
- 3 times a week
- Estimated price
- $24–50
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Indianapolis Union Station to St Louis Bus Station
- Ave. Duration
- 3h 55m
- Frequency
- 3 times a day
- Estimated price
- $40–75
- Website
- https://www.greyhound.com/
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More Questions & Answers
Yes, the driving distance between Indianapolis to Saint Charles is 257 miles. It takes approximately 4h 19m to drive from Indianapolis to Saint Charles.
There are 201+ hotels available in Saint Charles.





