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How to get fromIndianapolis to Sioux Fallsby plane, bus (Greyhound), train, bus, car, or bus (Flixbus)

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There are 8 ways to get from Indianapolis to Sioux Falls by plane, bus (Greyhound), train, bus, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Indianapolis

    best
    1. Fly from Indianapolis (IND) to Sioux Falls (FSD)plane plane IND - FSD
    7h 6m
    $84–464

  2. Bus

    1. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    2. Take the bus from Des Moines to Omaha, NEbus bus
    3. Take the bus from Omaha to Sioux Fallsbus bus
    19h 38m
    $136–240

  3. Train, bus

    1. Take the train from Indianapolis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from Minneapolis to Fairmontbus bus
    4. Take the bus from Fairmont to Sioux Fallsbus bus
    21h 46m
    $252–495

  4. Drive 732.3 mi

    1. Drive from Indianapolis to Sioux Fallscar car 732.3 mi
    12h 22m
    $134–193

  5. Train to Purdue University Airport, fly

    1. Take the train from Indianapolis to Lafayette Amtrak Stationtrain train
    2. Fly from Purdue University Airport (LAF) to Sioux Falls (FSD)plane plane LAF - FSD
    8h 41m
    $88–417

  6. Bus to Fort Wayne International Airport, fly

    1. Take the bus from Indianapolis, IN to Fort Wayne, INbus bus
    2. Fly from Fort Wayne International Airport (FWA) to Sioux Falls (FSD)plane plane FWA - FSD
    8h 59m
    $104–458

  7. Bus to Covington, fly

    1. Take the bus from Indianapolis to Cincinnatibus bus
    2. Fly from Covington (CVG) to Sioux Falls (FSD)plane plane CVG - FSD
    9h 48m
    $119–582

  8. Bus via Milwaukee Airport (MKE)

    1. Take the bus from Indianapolis to Milwaukee Mitchell Airportbus bus
    2. Take the bus from Milwaukee Mitchell Airport to Minneapolis Bus Stationbus bus
    3. Take the bus from Minneapolis to Sioux Fallsbus bus
    22h 33m
    $154–246

Indianapolis (IND) to Sioux Falls (FSD) flights

Calendar117Weekly Planes
Duration5h 18mAverage Duration
Ticket$83Cheapest Price
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Questions & Answers

Map of how to get from Indianapolis to Sioux Falls.ExpandLaunch map view
  • Distance: 622.3 mi
  • Duration: 7h 6m

What companies run services between Indianapolis, IN, USA and Sioux Falls, SD, USA?

Delta, United Airlines, and American Airlines fly from Indianapolis (IND) to Sioux Falls (FSD) hourly. Alternatively, you can take a bus from Indianapolis Union Station to The Bus Stop via Des Moines, Omaha, Sioux Falls, and Maple/Career NE corner in around 19h 38m.

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