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How to get fromIndianapolis to Syracuseby plane, bus, train, bus (Greyhound), car, or train (Amtrak)

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There are 7 ways to get from Indianapolis to Syracuse by plane, bus, train, bus (Greyhound), car, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Syracuse Hancock International Airport

    best
    1. Fly from Indianapolis (IND) to Syracuse Hancock International Airport (SYR)plane plane IND - SYR
    7h 27m
    $153–860

  2. Bus

    cheapest
    1. Take the bus from Indianapolis, IN to Toledobus bus
    2. Take the bus from Toledo Bus Stop to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland Bus Station to Syracuse Bus Stationbus bus
    14h 30m
    $87–199

  3. Bus, train

    1. Take the bus from Indianapolis, IN to Toledobus bus Cincinnati
    2. Take the train from Toledo to Syracuse Regional Transportation Centertrain train Lake Shore Limited
    12h 52m
    $152–350

  4. Drive 639.3 mi

    1. Drive from Indianapolis to Syracusecar car 639.3 mi
    11h 6m
    $117–169

  5. Fly to Rochester, train

    1. Fly from Indianapolis (IND) to Rochester (ROC)plane plane IND - ROC
    2. Take the train from Rochester to Syracuse Regional Transportation Centertrain train
    7h 45m
    $171–944

  6. Fly to Ithaca Tompkins Regional Airport, bus

    1. Fly from Indianapolis (IND) to Ithaca Tompkins Regional Airport (ITH)plane plane IND - ITH
    2. Take the bus from Ithaca to Syracuse Bus Stationbus bus
    9h 23m
    $106–499

  7. Train (Amtrak)

    1. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to Syracuse Regional Transportation Centertrain train Lake Shore Limited
    18h 58m
    $272–569

Indianapolis to Syracuse by bus and train

Calendar7Weekly Services
Duration12h 52mAverage Duration
Ticket$152Cheapest Price
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Questions & Answers

Map of how to get from Indianapolis to Syracuse.ExpandLaunch map view
  • Distance: 604.7 mi
  • Duration: 7h 27m

What companies run services between Indianapolis, IN, USA and Syracuse, NY, USA?

United Airlines, Delta, and American Airlines fly from Indianapolis (IND) to Syracuse Hancock International Airport (SYR) hourly. Alternatively, you can take a bus from Indianapolis, IN to Syracuse Bus Station via Toledo Bus Stop and Cleveland Bus Station in around 14h 30m.

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