There are 6 ways to get from Indianapolis to Winston-Salem by plane, bus (Flixbus, Greyhound), car, bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Piedmont Triad International Airport
best- Fly from Indianapolis (IND) to Piedmont Triad International Airport (GSO)plane IND - GSO
6h 35m$161–875Bus
cheapest- Take the bus from Indianapolis to Columbusbus FlixBus 2511 / ...
- Take the bus from Columbus to Winston Salem(Trans Center)bus Greyhound US0140
14h 14m$94–153Drive 512 mi
- Drive from Indianapolis to Winston-Salemcar 512 mi
9h 6m$94–135Fly to Charlotte Douglas International Airport, bus
- Fly from Indianapolis (IND) to Charlotte Douglas International Airport (CLT)plane IND - CLT
- Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus
6h 41m$108–648Fly to Raleigh-Durham International Airport, bus
- Fly from Indianapolis (IND) to Raleigh-Durham International Airport (RDU)plane IND - RDU
- Take the bus from Durham to Winston Salem(Trans Center)bus
7h 44m$180–398Train, bus
- Take the train from Indianapolis to Ashland Amtrak Stationtrain Cardinal
- Take the bus from Ashland Bus Station to Winston Salem(Trans Center)bus Greyhound US0140
14h 35m$116–230
Indianapolis to Winston-Salem by bus
Comparing Your Travel Options
The cheapest way to get from Indianapolis to Winston-Salem is to bus which costs $90 - $160 and takes 14h 14m.
The fastest way to get from Indianapolis to Winston-Salem is to fly which takes 6h 35m and costs $160 - $900.
No, there is no direct bus from Indianapolis to Winston-Salem. However, there are services departing from Indianapolis and arriving at Winston Salem(Trans Center) via E Main St & S High St and Columbus. The journey, including transfers, takes approximately 14h 14m.
The distance between Indianapolis and Winston-Salem is 469 miles. The road distance is 515 miles.
The best way to get from Indianapolis to Winston-Salem without a car is to bus which takes 14h 14m and costs $90 - $160.
It takes approximately 6h 35m to get from Indianapolis to Winston-Salem, including transfers.
Indianapolis to Winston-Salem bus services, operated by Flixbus USA, depart from Indianapolis station.
The best way to get from Indianapolis to Winston-Salem is to fly which takes 6h 35m and costs $160 - $900. Alternatively, you can bus, which costs $90 - $160 and takes 14h 14m.
Indianapolis to Winston-Salem bus services, operated by Flixbus USA, arrive at Columbus station.
Yes, the driving distance between Indianapolis to Winston-Salem is 515 miles. It takes approximately 9h 6m to drive from Indianapolis to Winston-Salem.
What companies run services between Indianapolis, IN, USA and Winston-Salem, NC, USA?
Delta, American Airlines, and United Airlines fly from Indianapolis (IND) to Piedmont Triad International Airport (GSO) hourly. Alternatively, you can take a bus from Indianapolis to Winston Salem(Trans Center) via Columbus, E Main St & S High St, S Grant Ave & E Mound St, and Columbus in around 14h 14m.
- Website
- aa.com
Flights from Indianapolis to Piedmont Triad International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 7m
- When
- Every day
- Estimated price
- $140–850
Flights from Indianapolis to Piedmont Triad International Airport via Reagan Washington
- Ave. Duration
- 3h 58m
- When
- Every day
- Estimated price
- $180–950
Flights from Indianapolis to Piedmont Triad International Airport via Philadelphia
- Ave. Duration
- 4h 56m
- When
- Every day
- Estimated price
- $210–1,100
Flights from Indianapolis to Piedmont Triad International Airport via Chicago O'Hare
- Ave. Duration
- 5h 9m
- When
- Every day
- Estimated price
- $180–950
Flights from Indianapolis to Charlotte Douglas International Airport
- Ave. Duration
- 1h 43m
- When
- Every day
- Estimated price
- $95–600
Flights from Indianapolis to Raleigh-Durham International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 3h 36m
- When
- Every day
- Estimated price
- $90–550
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Indianapolis to Ashland Amtrak Station
- Ave. Duration
- 6h 30m
- Frequency
- 3 times a week
- Estimated price
- $70–160
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Indianapolis to Columbus
- Ave. Duration
- 3h 30m
- Frequency
- Twice daily
- Estimated price
- $27–40
- Schedules at
- Flixbus USA
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Booking & Getting There
Book your Indianapolis to Winston-Salem bus tickets online with Omio.
There are 145+ hotels available in Winston-Salem.




