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How to get fromIndianapolis to Winston-Salemby plane, bus (Flixbus, Greyhound), car, bus, or bus (Greyhound)

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There are 6 ways to get from Indianapolis to Winston-Salem by plane, bus (Flixbus, Greyhound), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Piedmont Triad International Airport

    best
    1. Fly from Indianapolis (IND) to Piedmont Triad International Airport (GSO)plane plane IND - GSO
    6h 34m
    $171–975

  2. Bus via Charleston

    cheapest
    1. Take the bus from Indianapolis Union Station to Wilson & Ferrell Shell Station - Columbusbus bus
    2. Take the bus from Columbus to Charlestonbus bus
    3. Take the bus from Charleston Bus Station to Winston Salem(Trans Center)bus bus
    16h 5m
    $83–164

  3. Bus

    1. Take the bus from Indianapolis to Columbusbus bus FlixBus 2511 / ...
    2. Take the bus from Columbus to Winston Salem(Trans Center)bus bus Greyhound US0140
    14h 3m
    $94–153

  4. Drive  512 mi

    1. Drive from Indianapolis to Winston-Salemcar car 512 mi
    9h 6m
    $94–135

  5. Fly to Charlotte Douglas International Airport, bus

    1. Fly from Indianapolis (IND) to Charlotte Douglas International Airport (CLT)plane plane IND - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    6h 39m
    $118–678

  6. Fly to Raleigh-Durham International Airport, bus

    1. Fly from Indianapolis (IND) to Raleigh-Durham International Airport (RDU)plane plane IND - RDU
    2. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    7h 47m
    $180–398

Indianapolis to Winston-Salem by bus

Calendar7Weekly Buses
Duration14h 3mAverage Duration
Ticket$94Cheapest Price
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Comparing Your Travel Options

Map of how to get from Indianapolis to Winston-Salem.ExpandLaunch map view
  • Distance: 465.8 mi
  • Duration: 6h 34m

What companies run services between Indianapolis, IN, USA and Winston-Salem, NC, USA?

American Airlines, United Airlines, and Delta fly from Indianapolis (IND) to Piedmont Triad International Airport (GSO) hourly. Alternatively, you can take a bus from Indianapolis to Winston Salem(Trans Center) via Columbus, E Main St & S High St, S Grant Ave & E Mound St, and Columbus in around 14h 3m.

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