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How to get fromInterlaken to Sienaby train (Trenitalia), bus, car, train, or plane

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There are 7 ways to get from Interlaken to Siena by train (Trenitalia), bus, car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Spiez to Domodossolatrain train Ec / ...
    2. Take the train from Domodossola to Milano Centraletrain train Ec
    3. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    9h 4m
    €92–225

  2. Train via Rho

    cheapest
    1. Take the train from Spiez to Domodossolatrain train Ec / ...
    2. Take the train from Domodossola to Rho-Fiera Milanotrain train Re
    3. Take the train from Rho-Fiera Milano to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    10h 43m
    €90–178

  3. Bus

    1. Take the bus from Interlaken Sonnenhof to Zürich HB Schweizerhofbus bus
    2. Take the bus from ZÜRICH, Carparkplatz am Sihlquai to Milano - Famagostabus bus
    3. Take the bus from Milano - Famagosta to Florence Villa Constanza Bus Stationbus bus
    4. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 443 / ...
    10h 52m

  4. Drive 622.2 km

    1. Drive from Interlaken to Sienacar car 622.2 km
    6h 45m
    €108–156

  5. Train, fly to Florence Peretola Airport

    1. Take the train from Interlaken West to Zürich Flughafentrain train
    2. Fly from Zurich Airport (ZRH) to Florence Peretola Airport (FLR)plane plane ZRH - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    7h 38m
    €179–457

  6. Train, bus

    1. Take the train from Spiez to Domodossolatrain train Ec / ...
    2. Take the bus from Domodossola to Rho Fiera Milanobus bus Re4
    3. Take the train from Rho-Fiera Milano to Florence Santa Maria Novellatrain train
    4. Take the bus from Firenze Autostazione to Siena-Via Tozzibus bus 131
    9h 39m

  7. Train, fly to Bologna Guglielmo Marconi Airport

    1. Take the train from Interlaken West to Zürich Flughafentrain train
    2. Fly from Zurich Airport (ZRH) to Bologna Guglielmo Marconi Airport (BLQ)plane plane ZRH - BLQ
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train
    4. Take the train from Firenze S.M.N. to Sienatrain train
    8h 7m
    €171–472

Interlaken to Siena by train

Calendar4Weekly Trains
Duration9h 4mAverage Duration
Ticket€92Cheapest Price
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Questions & Answers

Map of how to get from Interlaken to Siena.ExpandLaunch map view
  • Distance: 634.2 km
  • Duration: 9h 4m

What companies run services between Interlaken, Switzerland and Siena, Italy?

You can take a train from Interlaken West to Siena via Spiez, Domodossola, Milano Centrale, and Firenze S.M.N. in around 9h 4m. Alternatively, you can take a bus from Interlaken Sonnenhof to Siena via Zürich HB Schweizerhof, ZÜRICH, Carparkplatz am Sihlquai, Milano - Famagosta, and Florence Villa Constanza Bus Station in around 10h 52m.

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