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How to get fromIowa City to Buffaloby bus, plane, bus (Greyhound), train, or car

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There are 8 ways to get from Iowa City to Buffalo by bus, plane, bus (Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Quad City International Airport, fly to Buffalo Niagara International Airport

    best
    1. Take the bus from Iowa City to Moline Center Stationbus bus
    2. Fly from Quad City International Airport (MLI) to Buffalo Niagara International Airport (BUF)plane plane MLI - BUF
    8h 29m
    $116–644

  2. Bus

    cheapest
    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Take the bus from Chicago to Clevelandbus bus
    3. Take the bus from Cleveland to Buffalobus bus
    16h 50m
    $87–198

  3. Bus, train

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    17h 38m
    $331–648

  4. Drive  738.8 mi

    1. Drive from Iowa City to Buffalocar car 738.8 mi
    12h 26m
    $135–195

  5. Bus to The Eastern Iowa Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Buffalo Niagara International Airport (BUF)plane plane CID - BUF
    8h 45m

  6. Bus to Chicago O'Hare International Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)plane plane ORD - BUF
    9h 40m
    $219–394

  7. Bus to Chicago Midway International Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane plane MDW - BUF
    9h 34m
    $206–461

  8. Bus to The Eastern Iowa Airport, fly to Toronto Pearson International Airport, bus

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Toronto Pearson International Airport (YYZ)plane plane CID - YYZ
    3. Take the bus from Toronto Pearson Airport to Buffalobus bus
    12h 23m

Iowa City to Buffalo by bus

Calendar7Weekly Buses
Duration16h 50mAverage Duration
Ticket$87Cheapest Price
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Comparing Your Travel Options

Map of how to get from Iowa City to Buffalo.ExpandLaunch map view
  • Distance: 686.5 mi
  • Duration: 8h 29m

What companies run services between Iowa City, IA, USA and Buffalo, NY, USA?

You can take a bus from Iowa City to Buffalo via Chicago and Cleveland in around 16h 50m.

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