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How to get fromIowa City to Cape Girardeauby bus, train, taxi, car, plane, or bus (Greyhound)

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There are 10 ways to get from Iowa City to Cape Girardeau by bus, train, taxi, car, plane, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train, taxi

    best
    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Carbondaletrain train
    3. Take the taxi from Carbondale to Cape Girardeautaxi taxi
    12h 24m
    $234–404

  2. Drive 357.6 mi

    cheapest
    1. Drive from Iowa City to Cape Girardeaucar car 357.6 mi
    6h 22m
    $66–95

  3. Bus to The Eastern Iowa Airport, fly to Williamson County Regional Airport, taxi

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Williamson County Regional Airport (MWA)plane plane CID - MWA
    3. Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi taxi
    8h 23m

  4. Bus, train

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    13h 49m
    $148–298

  5. Bus (Greyhound)

    1. Take the bus from Iowa City to Des Moinesbus bus
    2. Take the bus from Des Moines to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    14h 34m
    $101–196

  6. Bus to The Eastern Iowa Airport, fly to Barkley Regional Airport, taxi

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Barkley Regional Airport (PAH)plane plane CID - PAH
    3. Take the taxi from Barkley Regional Airport (PAH) to Cape Girardeautaxi taxi
    9h 55m

  7. Bus to Chicago O'Hare International Airport, fly to Cape Girardeau Municipal Airport

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Cape Girardeau Municipal Airport (CGI)plane plane ORD - CGI
    8h 43m
    $154–317

  8. Bus to Chicago O'Hare International Airport, fly to Williamson County Regional Airport, taxi

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA)plane plane ORD - MWA
    3. Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi taxi
    9h 24m
    $246–449

  9. Bus to Quad City International Airport, fly to Cape Girardeau Municipal Airport

    1. Take the bus from Iowa City to Moline Center Stationbus bus
    2. Fly from Quad City International Airport (MLI) to Cape Girardeau Municipal Airport (CGI)plane plane MLI - CGI
    8h 21m
    $143–536

  10. Bus to The Eastern Iowa Airport, fly to Cape Girardeau Municipal Airport

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Cape Girardeau Municipal Airport (CGI)plane plane CID - CGI
    8h 23m

The Eastern Iowa Airport (CID) to Williamson County Regional Airport (MWA) flights

Calendar26Weekly Planes
Duration4h 42mAverage Duration
Ticket$117Cheapest Price
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Questions & Answers

Map of how to get from Iowa City to Cape Girardeau.ExpandLaunch map view
  • Distance: 578.3 mi
  • Duration: 12h 24m

What companies run services between Iowa City, IA, USA and Cape Girardeau, MO, USA?

You can take a bus from Iowa City to Cape Girardeau via Des Moines, St Louis Bus Station, and Cape Girardeau in around 14h 34m.

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