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How to get fromIowa City to Great Smoky Mountainsby bus, plane, car, or train

Find Transport to Great Smoky Mountains

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There are 11 ways to get from Iowa City to Great Smoky Mountains by bus, plane, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Quad City International Airport, fly to Mcghee Tyson Airport, drive

    best
    1. Take the bus from Iowa City to Moline Center Stationbus bus
    2. Fly from Quad City International Airport (MLI) to Mcghee Tyson Airport (TYS)plane plane MLI - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    9h 21m
    $140–684

  2. Bus to Chicago O'Hare International Airport, fly to Asheville Regional Airport, drive

    cheapest
    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    3. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    10h 48m
    $110–430

  3. Bus, drive

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Union Station to Toledobus bus
    3. Take the bus from Toledo Bus Stop to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    29h 25m
    $229–408

  4. Bus, train, drive

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    38h 59m
    $436–933

  5. Drive 758.8 mi

    1. Drive from Iowa City to Great Smoky Mountainscar car 758.8 mi
    13h 53m
    $139–200

  6. Bus to The Eastern Iowa Airport, fly to Mcghee Tyson Airport, drive

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Mcghee Tyson Airport (TYS)plane plane CID - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    9h 18m

  7. Bus to The Eastern Iowa Airport, fly to Asheville Regional Airport, drive

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Asheville Regional Airport (AVL)plane plane CID - AVL
    3. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    9h 28m

  8. Bus to Quad City International Airport, fly to Hartsfield-Jackson Atlanta International Airport, drive

    1. Take the bus from Iowa City to Moline Center Stationbus bus
    2. Fly from Quad City International Airport (MLI) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane MLI - ATL
    3. Drive from Atlanta-Airport-ATL to Great Smoky Mountainscar car
    9h 31m
    $135–563

  9. Bus to The Eastern Iowa Airport, fly to Hartsfield-Jackson Atlanta International Airport, drive

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane CID - ATL
    3. Drive from Atlanta-Airport-ATL to Great Smoky Mountainscar car
    9h 25m

  10. Bus to Chicago O'Hare International Airport, fly to Mcghee Tyson Airport, drive

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    10h 28m
    $146–684

  11. Bus, drive via Columbus

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Take the bus from Chicago to N Wilson Rd & Ferrell Pl - Columbusbus bus
    3. Take the bus from Wilson & Ferrell Shell Station - Columbus to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from New Leicester Hwy at Walgreens to Great Smoky Mountainscar car
    30h 52m
    $160–338

Quad City International Airport (MLI) to Mcghee Tyson Airport (TYS) flights

Calendar76Weekly Planes
Duration5h 18mAverage Duration
Ticket$123Cheapest Price
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Questions & Answers

Map of how to get from Iowa City to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 650.2 mi
  • Duration: 9h 21m

What companies run services between Iowa City, IA, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Iowa City to Great Smoky Mountains. However, you can take the bus to Moline Center Station, walk to Centre Station, take the line 20 bus to QC Airport Shelter, walk to Quad City International Airport (MLI) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a bus from Iowa City to Great Smoky Mountains via Chicago Bus Station, Chicago Union Station, Toledo Bus Stop, Winston Salem(Trans Center), and Asheville, NC in around 29h 25m.

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