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How to get fromIowa City to Greenvilleby bus, plane, bus (Greyhound, Flixbus), train, car, or taxi

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There are 7 ways to get from Iowa City to Greenville by bus, plane, bus (Greyhound, Flixbus), train, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Quad City International Airport, fly to Greenville–Spartanburg International Airport

    best
    1. Take the bus from Iowa City to Moline Center Stationbus bus
    2. Fly from Quad City International Airport (MLI) to Greenville–Spartanburg International Airport (GSP)plane plane MLI - GSP
    7h 48m
    $155–663

  2. Bus

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    27h 5m
    $197–445

  3. Bus, train

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to Charlotte Amtrak Stationtrain train
    4. Take the bus from Charlotte to Taqueria Guadalajara - Greenvillebus bus
    38h 22m
    $480–1,085

  4. Drive 844.1 mi

    1. Drive from Iowa City to Greenvillecar car 844.1 mi
    15h 37m
    $155–223

  5. Bus to The Eastern Iowa Airport, fly to Greenville–Spartanburg International Airport

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Greenville–Spartanburg International Airport (GSP)plane plane CID - GSP
    8h 6m

  6. Bus to The Eastern Iowa Airport, fly to Asheville Regional Airport, taxi

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Asheville Regional Airport (AVL)plane plane CID - AVL
    3. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    8h 24m

  7. Bus to Chicago O'Hare International Airport, fly to Greenville–Spartanburg International Airport

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP)plane plane ORD - GSP
    9h 8m
    $166–663

Quad City International Airport (MLI) to Greenville–Spartanburg International Airport (GSP) flights

Calendar69Weekly Planes
Duration5h 19mAverage Duration
Ticket$113Cheapest Price
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Questions & Answers

Map of how to get from Iowa City to Greenville.ExpandLaunch map view
  • Distance: 716.7 mi
  • Duration: 7h 48m

What companies run services between Iowa City, IA, USA and Greenville, SC, USA?

You can take a bus from Iowa City to Greenville via Chicago Bus Station, Atlanta Bus Station, Garnett Station, Doraville Station, Atlanta, and Taqueria Guadalajara - Greenville in around 27h 5m.

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