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How to get fromIowa City to Knoxvilleby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

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There are 7 ways to get from Iowa City to Knoxville by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from The Eastern Iowa Airport

    best
    1. Fly from The Eastern Iowa Airport (CID) to Mcghee Tyson Airport (TYS)plane plane CID - TYS
    6h 8m
    $325–1,434

  2. Drive 702.3 mi

    cheapest
    1. Drive from Iowa City to Knoxvillecar car 702.3 mi
    12h 4m
    $129–186

  3. Bus

    1. Take the bus from Iowa City to Chicagobus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    35h 46m
    $361–564

  4. Bus, train

    1. Take the bus from Iowa City to Chicagobus bus
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    38h 59m
    $531–974

  5. Bus to Quad City International Airport, fly

    1. Take the bus from Iowa City to Molinebus bus
    2. Fly from Quad City International Airport (MLI) to Mcghee Tyson Airport (TYS)plane plane MLI - TYS
    7h 46m
    $185–789

  6. Bus, train via Ossining

    1. Take the bus from Iowa City to Napervillebus bus
    2. Take the train from Naperville to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 31m

  7. Bus via St. Louis

    1. Take the bus from Iowa City to Saint Louisbus bus
    2. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    46h 27m

The Eastern Iowa Airport (CID) to Mcghee Tyson Airport (TYS) flights

Calendar72Weekly Planes
Duration5h 51mAverage Duration
Ticket$269Cheapest Price
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Questions & Answers

Map of how to get from Iowa City to Knoxville.ExpandLaunch map view
  • Distance: 626.4 mi
  • Duration: 6h 8m

What companies run services between Iowa City, IA, USA and Knoxville, TN, USA?

Delta, United Airlines, and two other airlines fly from The Eastern Iowa Airport (CID) to Mcghee Tyson Airport (TYS) every 3 hours. Alternatively, you can take a bus from Iowa City to Knoxville via Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 35h 46m.

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