There are 9 ways to get from Iowa City to San Antonio by bus, plane, bus (Greyhound), train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Quad City International Airport, fly to San Antonio International Airport
best- Take the bus from Iowa City to Moline Center Stationbus
- Fly from Quad City International Airport (MLI) to San Antonio International Airport (SAT)plane MLI - SAT
8h 25m$132–620Bus via Omaha
- Take the bus from Iowa City to Omaha, NEbus Greyhound US0123S
- Take the bus from Omaha to San Antoniobus Omaha-Aguascalientes
28h 25m$278–313Bus, train
- Take the bus from Iowa City to Chicago Bus Stationbus Greyhound US0123S / ...
- Take the train from Chicago Union Station to San Antonio Stationtrain Texas Eagle
38h 30m$454–964Drive 1,064.8 mi
- Drive from Iowa City to San Antoniocar 1,064.8 mi
17h 52m$195–281Bus to The Eastern Iowa Airport, fly to San Antonio International Airport
- Take the bus from Court St Transportation Center to GTC Bay 9bus
- Fly from The Eastern Iowa Airport (CID) to San Antonio International Airport (SAT)plane CID - SAT
8h 31mBus to Des Moines, fly to San Antonio International Airport
- Take the bus from Iowa City to Des Moinesbus
- Fly from Des Moines (DSM) to San Antonio International Airport (SAT)plane DSM - SAT
9h 24m$257–1,146Bus to The Eastern Iowa Airport, fly to Austin-Bergstrom International Airport, bus
- Take the bus from Court St Transportation Center to GTC Bay 9bus
- Fly from The Eastern Iowa Airport (CID) to Austin-Bergstrom International Airport (AUS)plane CID - AUS
- Take the bus from Austin Eastside Bus Plaza to San Antonio Bus Stationbus
11h 3mBus to Chicago O'Hare International Airport, fly to San Antonio International Airport
- Take the bus from Iowa City to Chicago Bus Stationbus
- Fly from Chicago O'Hare International Airport (ORD) to San Antonio International Airport (SAT)plane ORD - SAT
10h 24m$208–621Bus
- Take the bus from Iowa City to Chicago Bus Stationbus Greyhound US0123S / ...
- Take the bus from Chicago to Tornado Bus Co - San Antoniobus Chicago
31h 6m$219–409
Iowa City to San Antonio by bus
Questions & Answers
The cheapest way to get from Iowa City to San Antonio is to drive which costs $190 - $290 and takes 17h 52m.
The fastest way to get from Iowa City to San Antonio is to bus and fly which takes 8h 25m and costs $130 - $650.
No, there is no direct bus from Iowa City to San Antonio. However, there are services departing from Iowa City and arriving at S. Flores & Cesar Chavez Blvd via 16th & Jackson NW, Omaha and W. Southcross & Buffalo. The journey, including transfers, takes approximately 28h 25m.
The distance between Iowa City and San Antonio is 1018 miles. The road distance is 1071 miles.
The best way to get from Iowa City to San Antonio without a car is to bus via Omaha which takes 28h 25m and costs $270 - $320.
It takes approximately 8h 25m to get from Iowa City to San Antonio, including transfers.
Iowa City to San Antonio bus services, operated by Greyhound USA, depart from Iowa City station.
Iowa City to San Antonio bus services, operated by Greyhound USA, arrive at Omaha, NE station.
Yes, the driving distance between Iowa City to San Antonio is 1071 miles. It takes approximately 17h 52m to drive from Iowa City to San Antonio.
Book your Iowa City to San Antonio bus tickets online with Omio.
What companies run services between Iowa City, IA, USA and San Antonio, TX, USA?
You can take a bus from Iowa City to S. Flores & Cesar Chavez Blvd via 16th & Jackson NW, Omaha, San Antonio, and W. Southcross & Buffalo in around 28h 25m.
- Website
- aa.com
Flights from Quad City International Airport to San Antonio International Airport via Dallas/Ft.Worth
- Ave. Duration
- 4h 19m
- When
- Every day
- Estimated price
- $120–600
Flights from Quad City International Airport to San Antonio International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 6h 20m
- When
- Every day
- Estimated price
- $140–650
Flights from The Eastern Iowa Airport to San Antonio International Airport via Dallas/Ft.Worth
- Ave. Duration
- 4h 50m
- When
- Every day
- Estimated price
- $240–1,200
Flights from The Eastern Iowa Airport to San Antonio International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 6h 47m
- When
- Every day
- Estimated price
- $290–1,400
Flights from Des Moines to San Antonio International Airport via Dallas/Ft.Worth
- Ave. Duration
- 4h 50m
- When
- Every day
- Estimated price
- $180–900
Flights from Des Moines to San Antonio International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 7h 6m
- When
- Every day
- Estimated price
- $240–1,100
Flights from The Eastern Iowa Airport to Austin-Bergstrom International Airport via Dallas/Ft.Worth
- Ave. Duration
- 4h 35m
- When
- Every day
- Estimated price
- $230–1,200
Flights from The Eastern Iowa Airport to Austin-Bergstrom International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 6h 46m
- When
- Every day
- Estimated price
- $290–1,300
Flights from Chicago O'Hare International Airport to San Antonio International Airport
- Ave. Duration
- 2h 51m
- When
- Every day
- Estimated price
- $130–600
Flights from Chicago O'Hare International Airport to San Antonio International Airport via Dallas/Ft.Worth
- Ave. Duration
- 4h 50m
- When
- Every day
- Estimated price
- $130–600
- Website
- united.com
Flights from Quad City International Airport to San Antonio International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 6h 20m
- When
- Every day
- Estimated price
- $140–650
Flights from Quad City International Airport to San Antonio International Airport via Denver
- Ave. Duration
- 7h 48m
- When
- Every day
- Estimated price
- $180–750
Flights from The Eastern Iowa Airport to San Antonio International Airport via Denver
- Ave. Duration
- 6h 40m
- When
- Every day
- Estimated price
- $340–1,500
Flights from The Eastern Iowa Airport to San Antonio International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 7h 24m
- When
- Every day
- Estimated price
- $290–1,400
Flights from Des Moines to San Antonio International Airport via Houston
- Ave. Duration
- 6h 5m
- When
- Every day
- Estimated price
- $190–950
Flights from Des Moines to San Antonio International Airport via Denver
- Ave. Duration
- 6h 32m
- When
- Every day
- Estimated price
- $250–1,100
Flights from Des Moines to San Antonio International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 7h 18m
- When
- Every day
- Estimated price
- $240–1,100
Flights from The Eastern Iowa Airport to Austin-Bergstrom International Airport via Denver
- Ave. Duration
- 6h 19m
- When
- Every day
- Estimated price
- $340–1,500
Flights from The Eastern Iowa Airport to Austin-Bergstrom International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 6h 37m
- When
- Every day
- Estimated price
- $290–1,300
Flights from Chicago O'Hare International Airport to San Antonio International Airport
- Ave. Duration
- 3h 3m
- When
- Every day
- Estimated price
- $130–600
Flights from Chicago O'Hare International Airport to San Antonio International Airport via Houston
- Ave. Duration
- 4h 56m
- When
- Every day
- Estimated price
- $130–650
- Website
- delta.com
Flights from Quad City International Airport to San Antonio International Airport via Atlanta
- Ave. Duration
- 6h 14m
- When
- Every day
- Estimated price
- $170–750
Flights from The Eastern Iowa Airport to San Antonio International Airport via Minneapolis
- Ave. Duration
- 5h 6m
- When
- Every day
- Estimated price
- $310–1,400
Flights from The Eastern Iowa Airport to San Antonio International Airport via Atlanta
- Ave. Duration
- 7h 38m
- When
- Every day
- Estimated price
- $350–1,500
Flights from Des Moines to San Antonio International Airport via Minneapolis
- Ave. Duration
- 5h 40m
- When
- Every day
- Estimated price
- $240–1,100
Flights from The Eastern Iowa Airport to Austin-Bergstrom International Airport via Minneapolis
- Ave. Duration
- 5h 26m
- When
- Every day
- Estimated price
- $300–1,400
Flights from The Eastern Iowa Airport to Austin-Bergstrom International Airport via Atlanta
- Ave. Duration
- 6h 29m
- When
- Every day
- Estimated price
- $350–1,500
- Website
- southwest.com
Flights from Des Moines to San Antonio International Airport via Chicago Midway
- Ave. Duration
- 7h 21m
- When
- Tuesday to Friday
- Estimated price
- $240–1,100
Flights from Des Moines to San Antonio International Airport via Denver
- Ave. Duration
- 8h 5m
- When
- Monday to Saturday
- Estimated price
- $250–1,100
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to San Antonio Station
- Ave. Duration
- 32h 36m
- Frequency
- Once daily
- Estimated price
- $420–900
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Iowa City to Moline Center Station
- Ave. Duration
- 1h 25m
- Frequency
- Once daily
- Estimated price
- $9–18
- Website
- https://www.greyhound.com/
Bus from Iowa City to Omaha, NE
- Ave. Duration
- 5h
- Frequency
- Once daily
- Estimated price
- $35–75
- Website
- https://www.greyhound.com/
Bus from Iowa City to Chicago Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- Twice daily
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
Bus from Iowa City to Des Moines
- Ave. Duration
- 2h 5m
- Frequency
- Twice daily
- Estimated price
- $16–35
- Website
- https://www.greyhound.com/
Bus from Austin Eastside Bus Plaza to San Antonio Bus Station
- Ave. Duration
- 1h 30m
- Frequency
- Every 4 hours
- Estimated price
- $12–23
- Website
- https://www.greyhound.com/
Bus from Iowa City to Chicago Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- Twice daily
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
Bus from Iowa City to Chicago Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- Twice daily
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
- Phone
- +52 449 291 3048
- [email protected]
- Website
- facebook.com
Bus from Omaha to San Antonio
- Ave. Duration
- 21h
- Frequency
- Twice a week
- Estimated price
- $238
- Schedules at
- facebook.com
- Phone
- +1-319-362-0375
- Website
- 380express.com
Bus from Court St Transportation Center to GTC Bay 9
- Ave. Duration
- 51 min
- Frequency
- Hourly
- Website
- https://www.380express.com
- Schedules at
- https://www.380express.com/schedule/
Bus from Court St Transportation Center to GTC Bay 9
- Ave. Duration
- 51 min
- Frequency
- Hourly
- Website
- https://www.380express.com
- Schedules at
- https://www.380express.com/schedule/
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Austin Eastside Bus Plaza to San Antonio Bus Station
- Ave. Duration
- 1h 30m
- Frequency
- 3 times a day
- Estimated price
- $12–22
- Schedules at
- flixbus.com
- Phone
- +1 888 358 6762
- [email protected]
- Website
- tornadobus.com
Bus from Chicago to Tornado Bus Co - San Antonio
- Ave. Duration
- 23h
- Frequency
- Once daily
- Estimated price
- $180–340
- Schedules at
- tornadobus.com
- Adults 11-59
- $180–340
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
More Questions & Answers
There are 1279+ hotels available in San Antonio.

















