What is the cheapest way to get from Iowa City to Sikeston?

The cheapest way to get from Iowa City to Sikeston is to drive which costs $70 - $110 and takes 6h 49m.

What is the fastest way to get from Iowa City to Sikeston?

The fastest way to get from Iowa City to Sikeston is to drive which takes 6h 49m and costs $70 - $110.

Is there a direct bus between Iowa City and Sikeston?

No, there is no direct bus from Iowa City to Sikeston. However, there are services departing from Iowa City and arriving at Flying J - Matthews via Jackson & Clinton, 35th/Archer Orange Line Station and Tornado Bus Co - Chicago. The journey, including transfers, takes approximately 14h 12m.

How far is it from Iowa City to Sikeston?

The distance between Iowa City and Sikeston is 646 miles. The road distance is 389.8 miles.

How do I travel from Iowa City to Sikeston without a car?

The best way to get from Iowa City to Sikeston without a car is to bus which takes 14h 12m and costs $150 - $210.

How long does it take to get from Iowa City to Sikeston?

It takes approximately 14h 12m to get from Iowa City to Sikeston, including transfers.

Where do I catch the Iowa City to Sikeston bus from?

Iowa City to Sikeston bus services, operated by Greyhound USA, depart from Iowa City station.

Where does the Iowa City to Sikeston bus arrive?

Iowa City to Sikeston bus services, operated by Greyhound USA, arrive at Chicago Bus Station.

Can I drive from Iowa City to Sikeston?

Yes, the driving distance between Iowa City to Sikeston is 390 miles. It takes approximately 6h 49m to drive from Iowa City to Sikeston.

Where can I stay near Sikeston?

There are 12+ hotels available in Sikeston.

Iowa City to Sikeston - 5 ways to travel via train, bus, car, and plane

How to get fromIowa City to Sikeston

Travel from

See all options

Search accommodation with Expedia

There are 5 ways to get from Iowa City to Sikeston by bus (Greyhound), bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Bus
best
1. Take the bus from Iowa City to Chicago Bus Stationbus Greyhound US0123S / ...
2. Take the bus from Tornado Bus Co - Chicago to Flying J - Matthewsbus Milwaukee
14h 12m
$152–206
Drive 387.5 mi
cheapest
1. Drive from Iowa City to Sikestoncar 387.5 mi
6h 49m
$71–103
Bus, train, drive
1. Take the bus from Iowa City to Chicago Bus Stationbus
2. Take the train from Chicago Union Station to Fulton Amtrak Stationtrain
3. Drive from Fulton Amtrak Station to Sikestoncar
15h 11m
$147–314
Bus, fly to Barkley Regional Airport, drive
1. Take the bus from Court St Transportation Center to GTC Bay 9bus
2. Fly from The Eastern Iowa Airport (CID) to Barkley Regional Airport (PAH)plane CID - PAH
3. Drive from Barkley Regional Airport (PAH) to Sikestoncar
9h 54m
Bus, fly to Williamson County Regional Airport
1. Take the bus from Court St Transportation Center to GTC Bay 9bus
2. Fly from The Eastern Iowa Airport (CID) to Williamson County Regional Airport (MWA)plane CID - MWA
3. Take the bus from Marathon Gas Station - Marion to Flying J - Matthewsbus
11h 1m

The Eastern Iowa Airport (CID) to Barkley Regional Airport (PAH) flights

21Weekly Planes

6h 53mAverage Duration

$64Cheapest Price

See schedules

Questions & Answers

Map of how to get from Iowa City to Sikeston.

Launch map view

Distance: 642.4 mi
Duration: 14h 12m

What companies run services between Iowa City, IA, USA and Sikeston, MO, USA?

You can take a bus from Iowa City to Sikeston via Chicago Bus Station, Jackson & Clinton, Jackson & Wabash, Adams/Wabash, 35th/Archer, 35th/Archer Orange Line Station, California & 35th Street, Tornado Bus Co - Chicago, and Flying J - Matthews in around 14h 12m.

Airlines

Train operators

Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.