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How to get fromIowa City to Sikestonby bus, taxi, car, or plane

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There are 7 ways to get from Iowa City to Sikeston by bus, taxi, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, taxi

    best
    1. Take the bus from Iowa City to Saint Louisbus bus
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    3. Take the taxi from Cape Girardeau to Sikestontaxi taxi
    10h 45m
    $200–273

  2. Drive 387.5 mi

    cheapest
    1. Drive from Iowa City to Sikestoncar car 387.5 mi
    6h 49m
    $71–103

  3. Bus to The Eastern Iowa Airport, fly to Barkley Regional Airport, drive

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Barkley Regional Airport (PAH)plane plane CID - PAH
    3. Drive from Barkley Regional Airport (PAH) to Sikestoncar car
    9h 37m

  4. Bus to The Eastern Iowa Airport, fly to Williamson County Regional Airport, bus

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Williamson County Regional Airport (MWA)plane plane CID - MWA
    3. Take the bus from Marathon Gas Station - Marion to Flying J - Matthewsbus bus
    10h 1m

  5. Bus to Chicago O'Hare International Airport, fly to Cape Girardeau Municipal Airport, taxi

    1. Take the bus from Iowa City to Napervillebus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Cape Girardeau Municipal Airport (CGI)plane plane ORD - CGI
    3. Take the taxi from Cape Girardeau Municipal Airport (CGI) to Sikestontaxi taxi
    9h 6m
    $236–396

  6. Bus to Quad City International Airport, fly to Cape Girardeau Municipal Airport, taxi

    1. Take the bus from Iowa City to Moline Center Stationbus bus
    2. Fly from Quad City International Airport (MLI) to Cape Girardeau Municipal Airport (CGI)plane plane MLI - CGI
    3. Take the taxi from Cape Girardeau Municipal Airport (CGI) to Sikestontaxi taxi
    8h 40m
    $216–626

  7. Bus to The Eastern Iowa Airport, fly to Cape Girardeau Municipal Airport, taxi

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Cape Girardeau Municipal Airport (CGI)plane plane CID - CGI
    3. Take the taxi from Cape Girardeau Municipal Airport (CGI) to Sikestontaxi taxi
    8h 43m

The Eastern Iowa Airport (CID) to Barkley Regional Airport (PAH) flights

Calendar21Weekly Planes
Duration6h 48mAverage Duration
Ticket$129Cheapest Price
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Questions & Answers

Map of how to get from Iowa City to Sikeston.ExpandLaunch map view
  • Distance: 449.6 mi
  • Duration: 10h 45m

What companies run services between Iowa City, IA, USA and Sikeston, MO, USA?

There is no direct connection from Iowa City to Sikeston. However, you can take the bus to Saint Louis, take the bus to Cape Girardeau, then take the taxi to Sikeston. Alternatively, you can drive from Iowa City to Sikeston in around 6h 49m.

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