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How to get fromIowa City to Sikestonby bus (Greyhound), bus, train, car, plane, or taxi

Find Transport to Sikeston

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There are 9 ways to get from Iowa City to Sikeston by bus (Greyhound), bus, train, car, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Iowa City to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the bus from Tornado Bus Co - Chicago to Flying J - Matthewsbus bus Milwaukee
    14h 13m
    $151–205

  2. Drive  387.5 mi

    cheapest
    1. Drive from Iowa City to Sikestoncar car 387.5 mi
    6h 49m
    $71–103

  3. Bus, train, drive

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Fulton Amtrak Stationtrain train
    3. Drive from Fulton Amtrak Station to Sikestoncar car
    15h 11m
    $269–426

  4. Bus to The Eastern Iowa Airport, fly to Barkley Regional Airport, drive

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Barkley Regional Airport (PAH)plane plane CID - PAH
    3. Drive from Barkley Regional Airport (PAH) to Sikestoncar car
    10h 4m

  5. Bus to Chicago O'Hare International Airport, fly to Cape Girardeau Municipal Airport, taxi

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Cape Girardeau Municipal Airport (CGI)plane plane ORD - CGI
    3. Take the taxi from Cape Girardeau Municipal Airport (CGI) to Sikestontaxi taxi
    8h 54m
    $222–575

  6. Bus to The Eastern Iowa Airport, fly to Williamson County Regional Airport, bus

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Williamson County Regional Airport (MWA)plane plane CID - MWA
    3. Take the bus from Marathon Gas Station - Marion to Flying J - Matthewsbus bus
    11h 9m

  7. Bus to Chicago O'Hare International Airport, fly to Barkley Regional Airport, drive

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Barkley Regional Airport (PAH)plane plane ORD - PAH
    3. Drive from Barkley Regional Airport (PAH) to Sikestoncar car
    9h 28m
    $92–360

  8. Bus to Quad City International Airport, fly to Cape Girardeau Municipal Airport, taxi

    1. Take the bus from Iowa City to Moline Center Stationbus bus
    2. Fly from Quad City International Airport (MLI) to Cape Girardeau Municipal Airport (CGI)plane plane MLI - CGI
    3. Take the taxi from Cape Girardeau Municipal Airport (CGI) to Sikestontaxi taxi
    8h 20m
    $191–616

  9. Bus to The Eastern Iowa Airport, fly to Cape Girardeau Municipal Airport, taxi

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Cape Girardeau Municipal Airport (CGI)plane plane CID - CGI
    3. Take the taxi from Cape Girardeau Municipal Airport (CGI) to Sikestontaxi taxi
    8h 43m

The Eastern Iowa Airport (CID) to Barkley Regional Airport (PAH) flights

Calendar21Weekly Planes
Duration7h 3mAverage Duration
Ticket$63Cheapest Price
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Comparing Your Travel Options

Map of how to get from Iowa City to Sikeston.ExpandLaunch map view
  • Distance: 643.3 mi
  • Duration: 14h 13m

What companies run services between Iowa City, IA, USA and Sikeston, MO, USA?

You can take a bus from Iowa City to Sikeston via Chicago Bus Station, LaSalle/Van Buren, 35th/Archer, 35th/Archer Orange Line Station, California & 35th Street, Tornado Bus Co - Chicago, and Flying J - Matthews in around 14h 13m.

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