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How to get fromIowa City to Sioux Fallsby bus (Greyhound), car, bus, or plane

Find Transport to Sioux Falls

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There are 6 ways to get from Iowa City to Sioux Falls by bus (Greyhound), car, bus, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Iowa City to Des Moinesbus bus
    2. Take the bus from Des Moines to Omaha, NEbus bus
    3. Take the bus from Omaha to Sioux Fallsbus bus
    10h 19m
    $106–156

  2. Drive  355.8 mi

    cheapest
    1. Drive from Iowa City to Sioux Fallscar car 355.8 mi
    7h 14m
    $65–94

  3. Bus to The Eastern Iowa Airport, fly

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Sioux Falls (FSD)plane plane CID - FSD
    8h 14m

  4. Bus to Quad City International Airport, fly

    1. Take the bus from Iowa City to Moline Center Stationbus bus
    2. Fly from Quad City International Airport (MLI) to Sioux Falls (FSD)plane plane MLI - FSD
    8h 40m
    $79–398

  5. Bus to Des Moines, fly

    1. Take the bus from Iowa City to Des Moinesbus bus
    2. Fly from Des Moines (DSM) to Sioux Falls (FSD)plane plane DSM - FSD
    8h 44m
    $134–592

  6. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Sioux Falls (FSD)plane plane ORD - FSD
    9h 53m
    $91–368

The Eastern Iowa Airport (CID) to Sioux Falls (FSD) flights

Calendar106Weekly Planes
Duration5h 40mAverage Duration
Ticket$56Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Iowa City to Sioux Falls.ExpandLaunch map view
  • Distance: 446.9 mi
  • Duration: 10h 19m

What companies run services between Iowa City, IA, USA and Sioux Falls, SD, USA?

You can take a bus from Iowa City to Sioux Falls via Des Moines, Omaha, and Sioux Falls in around 10h 19m.

Airlines
Bus operators

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