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How to get fromIowa City to St. Louisby bus, train, bus (Greyhound), car, or plane

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There are 5 ways to get from Iowa City to St. Louis by bus, train, bus (Greyhound), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train

    best
    1. Take the bus from Iowa City to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    10h 40m
    $126–256

  2. Drive 258.9 mi

    cheapest
    1. Drive from Iowa City to St. Louiscar car 258.9 mi
    4h 41m
    $48–69

  3. Bus (Greyhound)

    1. Take the bus from Iowa City to Des Moinesbus bus Greyhound US0123S / ...
    2. Take the bus from Des Moines to St Louis Bus Stationbus bus Greyhound US0153S
    11h 20m
    $83–163

  4. Bus to Quad City International Airport, fly

    1. Take the bus from Iowa City to Moline Center Stationbus bus
    2. Fly from Quad City International Airport (MLI) to Lambert–St. Louis International Airport (STL)plane plane MLI - STL
    7h 42m
    $88–482

  5. Bus to The Eastern Iowa Airport, fly

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Lambert–St. Louis International Airport (STL)plane plane CID - STL
    7h 50m

Iowa City to St. Louis by bus, foot, and train

Calendar14Weekly Services
Duration10h 40mAverage Duration
Ticket$126Cheapest Price
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Questions & Answers

Map of how to get from Iowa City to St. Louis.ExpandLaunch map view
  • Distance: 504.1 mi
  • Duration: 10h 40m

What companies run services between Iowa City, IA, USA and St. Louis, MO, USA?

You can take a bus from Iowa City to St Louis Bus Station via Des Moines in around 11h 20m.

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