Rome2Rio

How to get fromIowa City to St. Louisby bus, train, car, plane, or bus (Greyhound, Flixbus)

Find Transport to St. Louis

See all options

There are 5 ways to get from Iowa City to St. Louis by bus, train, car, plane, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train

    best
    1. Take the bus from Iowa City to Chicago Bus Stationbus bus Greyhound US0155S / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    11h 40m
    $193–303

  2. Drive  258.9 mi

    cheapest
    1. Drive from Iowa City to St. Louiscar car 258.9 mi
    4h 41m
    $45–64

  3. Bus to Quad City International Airport, fly

    1. Take the bus from Iowa City to Moline Center Stationbus bus
    2. Fly from Quad City International Airport (MLI) to Lambert–St. Louis International Airport (STL)plane plane MLI - STL
    8h
    $90–490

  4. Bus

    1. Take the bus from Iowa City to Chicago Bus Stationbus bus Greyhound US0155S / ...
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    12h 40m
    $93–138

  5. Bus to The Eastern Iowa Airport, fly

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Lambert–St. Louis International Airport (STL)plane plane CID - STL
    7h 44m

Iowa City to St. Louis by bus, foot, and train

Calendar27Weekly Services
Duration11h 40mAverage Duration
Ticket$193Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Iowa City to St. Louis.ExpandLaunch map view
  • Distance: 515.4 mi
  • Duration: 11h 40m

What companies run services between Iowa City, IA, USA and St. Louis, MO, USA?

You can take a bus from Iowa City to St Louis Bus Station via Chicago Bus Station in around 12h 40m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There