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How to get fromIowa to Cape Girardeauby bus (Greyhound), bus, train, car, plane, taxi, or bus (Greyhound, Amtrak, Flixbus)

Find Transport to Cape Girardeau

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There are 6 ways to get from Iowa to Cape Girardeau by bus (Greyhound), bus, train, car, plane, taxi, or bus (Greyhound, Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Kansas City

    best
    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    11h 39m
    $112–191

  2. Drive  428.5 mi

    cheapest
    1. Drive from Des Moines to Cape Girardeaucar car 428.5 mi
    8h 19m
    $79–113

  3. Bus, train

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the train from Kansas City to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    13h 59m
    $147–286

  4. Fly Quad City International Airport to Williamson County Regional Airport, taxi

    1. Fly from Quad City International Airport (MLI) to Williamson County Regional Airport (MWA)plane plane MLI - MWA
    2. Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi taxi
    7h 21m
    $192–532

  5. Bus

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the bus from Springfield SMTD Transfer Center to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    14h 1m
    $109–190

  6. Fly Omaha to Lambert–St. Louis International Airport, bus

    1. Fly from Omaha (OMA) to Lambert–St. Louis International Airport (STL)plane plane OMA - STL
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    7h 51m
    $630–950

Quad City International Airport (MLI) to Williamson County Regional Airport (MWA) flights

Calendar14Weekly Planes
Duration5h 26mAverage Duration
Ticket$61Cheapest Price
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Questions & Answers

Map of how to get from Iowa to Cape Girardeau.ExpandLaunch map view
  • Distance: 557.2 mi
  • Duration: 11h 39m

What companies run services between Iowa, USA and Cape Girardeau, MO, USA?

You can take a bus from Des Moines to Cape Girardeau via Kansas City, Kansas City Bus Station, St Louis Bus Station, and Cape Girardeau in around 11h 39m.

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