Rome2Rio

How to get fromIowa to Great Smoky Mountainsby plane, car, bus, or train

Find Transport to Great Smoky Mountains

See all options

There are 9 ways to get from Iowa to Great Smoky Mountains by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Des Moines, drive

    best
    1. Fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS)plane plane DSM - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    6h 20m
    $258–1,237

  2. Fly from Quad City International Airport, drive

    cheapest
    1. Fly from Quad City International Airport (MLI) to Mcghee Tyson Airport (TYS)plane plane MLI - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    8h 11m
    $132–718

  3. Bus, drive

    1. Take the bus from Des Moines to Indianapolisbus bus
    2. Take the bus from Indianapolis to Columbusbus bus
    3. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    30h 37m

  4. Bus, train, drive

    1. Take the bus from Des Moines to Indianapolisbus bus
    2. Take the train from Indianapolis to Charlottesvilletrain train
    3. Take the train from Charlottesville to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    36h 41m

  5. Drive 868.8 mi

    1. Drive from Des Moines to Great Smoky Mountainscar car 868.8 mi
    15h 41m
    $159–229

  6. Fly from Omaha, drive

    1. Fly from Omaha (OMA) to Mcghee Tyson Airport (TYS)plane plane OMA - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    8h 16m
    $183–919

  7. Bus, drive via Chicago

    1. Take the bus from Des Moines to Chicagobus bus
    2. Take the bus from Chicago to N Wilson Rd & Ferrell Pl - Columbusbus bus
    3. Take the bus from Columbus to Charlottebus bus
    4. Take the bus from Charlotte Bus Station to Asheville, NCbus bus
    5. Drive from New Leicester Hwy at Walgreens to Great Smoky Mountainscar car
    32h 57m

  8. Bus, train, drive via Chicago

    1. Take the bus from Des Moines to Chicagobus bus
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    40h 25m

  9. Bus, train, drive via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Greensborotrain train
    5. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    6. Drive from Asheville, NC to Great Smoky Mountainscar car
    42h 17m

Des Moines (DSM) to Mcghee Tyson Airport (TYS) flights

Calendar83Weekly Planes
Duration5h 15mAverage Duration
Ticket$230Cheapest Price
See schedules

Questions & Answers

Map of how to get from Iowa to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 719.4 mi
  • Duration: 6h 20m

What companies run services between Iowa, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Iowa to Great Smoky Mountains. However, you can take the taxi to Des-Moines-Airport-DSM airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a bus from Des Moines to Great Smoky Mountains via Indianapolis, Indianapolis, Columbus, S 3Rd St & E Town St, E Livingston Ave & Macon Aly, Columbus, Winston Salem(Trans Center), and Asheville, NC in around 30h 37m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound