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How to get fromIowa to Greenvilleby plane, bus (Greyhound, Flixbus), car, bus, or train

Find Transport to Greenville

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There are 6 ways to get from Iowa to Greenville by plane, bus (Greyhound, Flixbus), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Des Moines

    best
    1. Fly from Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP)plane plane DSM - GSP
    4h 25m
    $243–1,016

  2. Fly from Quad City International Airport

    cheapest
    1. Fly from Quad City International Airport (MLI) to Greenville–Spartanburg International Airport (GSP)plane plane MLI - GSP
    6h 38m
    $147–647

  3. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    26h 21m
    $217–472

  4. Drive 954.2 mi

    1. Drive from Des Moines to Greenvillecar car 954.2 mi
    17h 25m
    $175–252

  5. Bus via Kansas City

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    26h 43m
    $239–492

  6. Bus, train

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the train from Kansas City to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    28h 45m
    $291–604

Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP) flights

Calendar79Weekly Planes
Duration5h 33mAverage Duration
Ticket$197Cheapest Price
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Questions & Answers

Map of how to get from Iowa to Greenville.ExpandLaunch map view
  • Distance: 789.7 mi
  • Duration: 4h 25m

What companies run services between Iowa, USA and Greenville, SC, USA?

Delta, American Airlines, and United Airlines fly from Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP) every 2 hours. Alternatively, you can take a vehicle from Des Moines to Greenville via Des Moines, St Louis Bus Station, Atlanta Bus Station, Garnett Station, Doraville Station, Atlanta, and Taqueria Guadalajara - Greenville in around 26h 21m.

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