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How to get fromIowa to Harrisburgby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

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There are 9 ways to get from Iowa to Harrisburg by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Quad City International Airport to Harrisburg International Airport

    best
    1. Fly from Quad City International Airport (MLI) to Harrisburg International Airport (MDT)plane plane MLI - MDT
    7h 37m
    $79–406

  2. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the bus from Chicago Bus Station to Harrisburg Bus Stationbus bus FlixBus N2640 / ...
    24h 5m
    $169–305

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Pittsburgh Amtrak Stationtrain train
    3. Take the train from Pittsburgh Amtrak Station to Harrisburgtrain train
    24h 9m
    $274–575

  4. Drive 971.6 mi

    1. Drive from Des Moines to Harrisburgcar car 971.6 mi
    16h 7m
    $178–257

  5. Fly Des Moines to Philadelphia International Airport, train

    1. Fly from Des Moines (DSM) to Philadelphia International Airport (PHL)plane plane DSM - PHL
    2. Take the train from 30th Street Station to Harrisburgtrain train
    6h 5m
    $211–894

  6. Bus to Chicago O'Hare International Airport, fly to Harrisburg International Airport

    1. Take the bus from Davenport to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Harrisburg International Airport (MDT)plane plane ORD - MDT
    9h 37m
    $91–410

  7. Fly Des Moines to Ronald Reagan Washington National Airport, train

    1. Fly from Des Moines (DSM) to Ronald Reagan Washington National Airport (DCA)plane plane DSM - DCA
    2. Take the train from Washington Union Station to 30th Street Stationtrain train
    3. Take the train from 30th Street Station to Harrisburgtrain train
    7h 54m
    $262–1,088

  8. Bus via Indianapolis (Greyhound)

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus Greyhound US0157S
    2. Take the bus from Indianapolis Union Station to Harrisburg Bus Stationbus bus Greyhound US0421
    25h 5m
    $154–310

  9. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Pittsburgh Amtrak Stationtrain train
    4. Take the train from Pittsburgh Amtrak Station to Harrisburgtrain train
    25h 20m
    $304–650

Quad City International Airport (MLI) to Harrisburg International Airport (MDT) flights

Calendar68Weekly Planes
Duration5h 51mAverage Duration
Ticket$76Cheapest Price
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Questions & Answers

Map of how to get from Iowa to Harrisburg.ExpandLaunch map view
  • Distance: 747.6 mi
  • Duration: 7h 37m

What companies run services between Iowa, USA and Harrisburg, Dauphin County, PA, USA?

United Airlines, Delta, and American Airlines fly from Quad City International Airport (MLI) to Harrisburg International Airport (MDT) every 3 hours. Alternatively, you can take a vehicle from Des Moines to Harrisburg Bus Station via Des Moines and Chicago Bus Station in around 24h 5m.

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