There are 4 ways to get from Iowa to Indianapolis by plane, bus (Greyhound), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Des Moines
best- Fly from Des Moines (DSM) to Indianapolis (IND)plane DSM - IND
4h 42m$106–575Fly from Quad City International Airport
cheapest- Fly from Quad City International Airport (MLI) to Indianapolis (IND)plane MLI - IND
6h 50m$74–474Bus (Greyhound)
- Take the bus from Des Moines to Indianapolis Union Stationbus Greyhound US0157S
9h 30m$88–140Drive 465.7 mi
- Drive from Des Moines to Indianapoliscar 465.7 mi
7h 54m$85–123
Des Moines (DSM) to Indianapolis (IND) flights
Comparing Your Travel Options
The cheapest way to get from Iowa to Indianapolis is to drive which costs $85 - $130 and takes 7h 54m.
The fastest way to get from Iowa to Indianapolis is to fly which takes 4h 42m and costs $100 - $600.
No, there is no direct bus from Iowa to Indianapolis station. However, there are services departing from Des Moines and arriving at Indianapolis Union Station via . The journey, including transfers, takes approximately 9h 30m.
The distance between Iowa and Indianapolis is 429 miles. The road distance is 468.4 miles.
The best way to get from Iowa to Indianapolis without a car is to bus which takes 9h 30m and costs $85 - $140.
It takes approximately 4h 42m to get from Iowa to Indianapolis, including transfers.
Iowa to Indianapolis bus services, operated by Greyhound USA, depart from Des Moines station.
The best way to get from Iowa to Indianapolis is to fly which takes 4h 42m and costs $100 - $600. Alternatively, you can bus, which costs $85 - $140 and takes 9h 30m.
Iowa to Indianapolis bus services, operated by Greyhound USA, arrive at Indianapolis Union Station.
Indianapolis is 1h ahead of Iowa. It is currently 4:01 PM in Iowa and 5:01 PM in Indianapolis.
What companies run services between Iowa, USA and Indianapolis, IN, USA?
Southwest Airlines, United Airlines, and two other airlines fly from Des Moines (DSM) to Indianapolis (IND) hourly. Alternatively, Greyhound USA operates a bus from Des Moines to Indianapolis Union Station once daily. Tickets cost $80–130 and the journey takes 9h 25m.
- Website
- aa.com
Flights from Des Moines to Indianapolis via Chicago O'Hare
- Ave. Duration
- 4h 28m
- When
- Every day
- Estimated price
- $85–550
Flights from Des Moines to Indianapolis via Charlotte
- Ave. Duration
- 5h 4m
- When
- Every day
- Estimated price
- $150–750
Flights from Quad City International Airport to Indianapolis via Chicago O'Hare
- Ave. Duration
- 5h 40m
- When
- Every day
- Estimated price
- $70–470
Flights from Quad City International Airport to Indianapolis via Charlotte
- Ave. Duration
- 5h 47m
- When
- Tuesday, Thursday, Friday, and Sunday
- Estimated price
- $140–700
Flights from Quad City International Airport to Indianapolis via Dallas/Ft.Worth
- Ave. Duration
- 6h 3m
- When
- Monday, Thursday, Friday, Sunday, and Wednesday
- Estimated price
- $170–800
- Website
- united.com
Flights from Des Moines to Indianapolis via Chicago O'Hare
- Ave. Duration
- 4h 4m
- When
- Every day
- Estimated price
- $85–550
Flights from Quad City International Airport to Indianapolis via Chicago O'Hare
- Ave. Duration
- 4h
- When
- Every day
- Estimated price
- $70–470
- Website
- delta.com
Flights from Des Moines to Indianapolis via Minneapolis
- Ave. Duration
- 4h 9m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–600
Flights from Des Moines to Indianapolis via Detroit
- Ave. Duration
- 5h
- When
- Every day
- Estimated price
- $110–600
Flights from Des Moines to Indianapolis via Atlanta
- Ave. Duration
- 4h 55m
- When
- Every day
- Estimated price
- $140–700
Flights from Quad City International Airport to Indianapolis via Atlanta
- Ave. Duration
- 5h 24m
- When
- Every day
- Estimated price
- $130–700
- Website
- southwest.com
Flights from Des Moines to Indianapolis via Chicago Midway
- Ave. Duration
- 5h
- When
- Saturday to Wednesday
- Estimated price
- $85–550
Flights from Des Moines to Indianapolis via Nashville
- Ave. Duration
- 5h 15m
- When
- Monday
- Estimated price
- $110–600
- Website
- allegiantair.com
Flights from Quad City International Airport to Indianapolis via Sarasota/Bradenton
- Ave. Duration
- 6h 10m
- When
- Friday
- Estimated price
- $210–950
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Des Moines to Indianapolis Union Station
- Ave. Duration
- 9h 25m
- Frequency
- Once daily
- Estimated price
- $80–130
- Website
- Greyhound
Want to know more about travelling around United States
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Booking & Getting There
Yes, the driving distance between Iowa to Indianapolis is 468 miles. It takes approximately 7h 54m to drive from Iowa to Indianapolis.
There are 740+ hotels available in Indianapolis.