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How to get fromIowa to Jacksonvilleby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 7 ways to get from Iowa to Jacksonville by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Des Moines to Jacksonville

    best
    1. Fly from Des Moines (DSM) to Jacksonville (JAX)plane plane DSM - JAX
    6h 26m
    $169–774

  2. Fly Quad City International Airport to Jacksonville

    cheapest
    1. Fly from Quad City International Airport (MLI) to Jacksonville (JAX)plane plane MLI - JAX
    7h 58m
    $98–475

  3. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Jacksonvillebus bus
    28h 35m
    $214–420

  4. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Jacksonvilletrain train Floridian
    44h 1m
    $560–1,213

  5. Drive 1,177.5 mi

    1. Drive from Des Moines to Jacksonvillecar car 1,177.5 mi
    22h 14m
    $215–311

  6. Fly Omaha to Jacksonville

    1. Fly from Omaha (OMA) to Jacksonville (JAX)plane plane OMA - JAX
    8h 23m
    $144–656

  7. Fly Des Moines to Orlando Sanford, drive

    1. Fly from Des Moines (DSM) to Orlando Sanford (SFB)plane plane DSM - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Jacksonvillecar car
    5h 20m
    $190–806

Des Moines (DSM) to Jacksonville (JAX) flights

Calendar81Weekly Planes
Duration6h 5mAverage Duration
Ticket$159Cheapest Price
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Questions & Answers

Map of how to get from Iowa to Jacksonville.ExpandLaunch map view
  • Distance: 1,037 mi
  • Duration: 6h 26m

What companies run services between Iowa, USA and Jacksonville, FL, USA?

American Airlines, United Airlines, and two other airlines fly from Des Moines (DSM) to Jacksonville (JAX) every 2 hours. Alternatively, you can take a vehicle from Des Moines to Jacksonville via Des Moines, St Louis Bus Station, and Atlanta Bus Station in around 28h 35m.

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