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How to get fromIowa to Jacksonvilleby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 7 ways to get from Iowa to Jacksonville by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Des Moines to Jacksonville

    best
    1. Fly from Des Moines (DSM) to Jacksonville (JAX)plane plane DSM - JAX
    6h 1m
    $160–726

  2. Fly Quad City International Airport to Jacksonville

    cheapest
    1. Fly from Quad City International Airport (MLI) to Jacksonville (JAX)plane plane MLI - JAX
    8h 9m
    $98–555

  3. Bus

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Jacksonvillebus bus
    28h 45m
    $223–372

  4. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Jacksonvilletrain train Floridian
    44h
    $439–1,048

  5. Drive  1,177.5 mi

    1. Drive from Des Moines to Jacksonvillecar car 1,177.5 mi
    22h 13m
    $215–311

  6. Fly Des Moines to Orlando Sanford, drive

    1. Fly from Des Moines (DSM) to Orlando Sanford (SFB)plane plane DSM - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Jacksonvillecar car
    5h 10m
    $171–708

  7. Fly Omaha to Jacksonville

    1. Fly from Omaha (OMA) to Jacksonville (JAX)plane plane OMA - JAX
    8h 28m
    $134–706

Iowa to Jacksonville by bus

Calendar12Weekly Buses
Duration28h 45mAverage Duration
Ticket$223Cheapest Price
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Comparing Your Travel Options

Map of how to get from Iowa to Jacksonville.ExpandLaunch map view
  • Distance: 1,037 mi
  • Duration: 6h 1m

What companies run services between Iowa, USA and Jacksonville, FL, USA?

Delta, Southwest Airlines, and two other airlines fly from Des Moines (DSM) to Jacksonville (JAX) hourly. Alternatively, you can take a bus from Des Moines to Jacksonville via Kansas City, Kansas City Bus Station, St Louis Bus Station, and Atlanta Bus Station in around 28h 45m.

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Want to know more about travelling around United States

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Need to know: Greyhound

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