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How to get fromIowa to Knoxvilleby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

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There are 8 ways to get from Iowa to Knoxville by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Des Moines to Mcghee Tyson Airport

    best
    1. Fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS)plane plane DSM - TYS
    4h 13m
    $314–1,493

  2. Drive  812.4 mi

    cheapest
    1. Drive from Des Moines to Knoxvillecar car 812.4 mi
    13h 52m
    $149–215

  3. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    41h 57m
    $391–578

  4. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    42h 5m
    $481–998

  5. Fly Quad City International Airport to Mcghee Tyson Airport

    1. Fly from Quad City International Airport (MLI) to Mcghee Tyson Airport (TYS)plane plane MLI - TYS
    6h 19m
    $207–972

  6. Fly Des Moines to Nashville, drive

    1. Fly from Des Moines (DSM) to Nashville (BNA)plane plane DSM - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    4h 34m
    $149–723

  7. Bus via Indianapolis

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    43h 3m
    $391–593

  8. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to Grand Central Terminaltrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    43h 54m
    $457–956

Des Moines (DSM) to Mcghee Tyson Airport (TYS) flights

Calendar59Weekly Planes
Duration5h 8mAverage Duration
Ticket$241Cheapest Price
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Comparing Your Travel Options

Map of how to get from Iowa to Knoxville.ExpandLaunch map view
  • Distance: 673 mi
  • Duration: 4h 13m

What companies run services between Iowa, USA and Knoxville, TN, USA?

Southwest Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS) every 4 hours. Alternatively, you can take a vehicle from Des Moines to Knoxville via Des Moines, Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 41h 57m.

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