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How to get fromIowa to Knoxvilleby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

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There are 9 ways to get from Iowa to Knoxville by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Des Moines

    best
    1. Fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS)plane plane DSM - TYS
    4h 33m
    $273–1,191

  2. Drive  812.4 mi

    cheapest
    1. Drive from Des Moines to Knoxvillecar car 812.4 mi
    13h 52m
    $149–215

  3. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    38h 52m
    $357–553

  4. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    42h 5m
    $487–953

  5. Fly from Waterloo Municipal Airport

    1. Fly from Waterloo Municipal Airport (ALO) to Mcghee Tyson Airport (TYS)plane plane ALO - TYS
    5h 16m
    $225–944

  6. Fly from Quad City International Airport

    1. Fly from Quad City International Airport (MLI) to Mcghee Tyson Airport (TYS)plane plane MLI - TYS
    6h 23m
    $197–872

  7. Fly from Omaha

    1. Fly from Omaha (OMA) to Mcghee Tyson Airport (TYS)plane plane OMA - TYS
    6h 41m
    $248–1,173

  8. Bus via Indianapolis

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    43h 18m
    $367–613

  9. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    43h 52m
    $466–895

Des Moines (DSM) to Mcghee Tyson Airport (TYS) flights

Calendar81Weekly Planes
Duration5h 10mAverage Duration
Ticket$203Cheapest Price
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Questions & Answers

Map of how to get from Iowa to Knoxville.ExpandLaunch map view
  • Distance: 673 mi
  • Duration: 4h 33m

What companies run services between Iowa, USA and Knoxville, TN, USA?

Delta, United Airlines, and American Airlines fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS) every 2 hours. Alternatively, you can take a vehicle from Des Moines to Knoxville via Des Moines, Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 38h 52m.

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Train operators
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