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How to get fromIowa to Lafayetteby bus (Greyhound, Amtrak), bus, train, car, or plane

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There are 8 ways to get from Iowa to Lafayette by bus (Greyhound, Amtrak), bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Chicago

    best
    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the bus from Chicago Union Station to Lafayette Amtrak Stationbus bus Chicago
    10h 49m
    $82–155

  2. Fly Quad City International Airport to Purdue University Airport

    cheapest
    1. Fly from Quad City International Airport (MLI) to Purdue University Airport (LAF)plane plane MLI - LAF
    8h 2m
    $48–303

  3. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    12h 31m
    $124–260

  4. Drive 412.8 mi

    1. Drive from Des Moines to Lafayettecar car 412.8 mi
    7h 30m
    $76–109

  5. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train Cardinal
    11h 20m
    $94–190

  6. Bus

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus Greyhound US0157S
    2. Take the bus from Indianapolis Union Station to Lafayette Amtrak Stationbus bus
    12h 5m
    $93–195

  7. Fly Des Moines to Chicago Midway International Airport, train

    1. Fly from Des Moines (DSM) to Chicago Midway International Airport (MDW)plane plane DSM - MDW
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    6h 24m
    $128–559

  8. Fly Quad City International Airport to Chicago O'Hare International Airport, train

    1. Fly from Quad City International Airport (MLI) to Chicago O'Hare International Airport (ORD)plane plane MLI - ORD
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    8h 23m
    $69–307

Quad City International Airport (MLI) to Purdue University Airport (LAF) flights

Calendar21Weekly Planes
Duration6h 11mAverage Duration
Ticket$45Cheapest Price
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Questions & Answers

Map of how to get from Iowa to Lafayette.ExpandLaunch map view
  • Distance: 457.1 mi
  • Duration: 10h 49m

What companies run services between Iowa, USA and Lafayette, IN, USA?

You can take a vehicle from Des Moines to Lafayette Amtrak Station via Des Moines, Chicago Bus Station, and Chicago Union Station in around 10h 49m. Alternatively, United Airlines and American Airlines fly from Quad City International Airport (MLI) to Purdue University Airport (LAF) 3 times a day.

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