There are 5 ways to get from Iowa to Mayo Clinic by bus, car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Des Moines to St. Paulbus Jefferson Lines 806 / ...
- Take the bus from St. Paul to Rochesterbus Jefferson Lines 965
7h 13m$93–129Drive 207.6 mi
cheapest- Drive from Des Moines to Mayo Cliniccar 207.6 mi
3h 28m$38–55Fly, bus
- Fly from Des Moines (DSM) to Minneapolis–Saint Paul International Airport (MSP)plane DSM - MSP
- Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
4h 35m$124–463Bus via Minneapolis Airport (MSP)
- Take the bus from Des Moines to St. Paulbus Jefferson Lines 806 / ...
- Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus Groome Transportation
8h 35m$117–142Bus via Minneapolis
- Take the bus from Des Moines to Minneapolisbus Jefferson Lines 804 / ...
- Take the bus from Minneapolis to Rochesterbus Jefferson Lines 965
9h 8m$95–135
Iowa to Mayo Clinic by bus and foot
Comparing Your Travel Options
The cheapest way to get from Iowa to Mayo Clinic is to drive which costs $35 - $55 and takes 3h 28m.
The fastest way to get from Iowa to Mayo Clinic is to drive which takes 3h 28m and costs $35 - $55.
No, there is no direct bus from Iowa to Mayo Clinic. However, there are services departing from Des Moines and arriving at Rochester via St. Paul. The journey, including transfers, takes approximately 7h 13m.
The distance between Iowa and Mayo Clinic is 332 miles. The road distance is 208.8 miles.
The best way to get from Iowa to Mayo Clinic without a car is to bus which takes 7h 13m and costs $90 - $130.
It takes approximately 7h 13m to get from Iowa to Mayo Clinic, including transfers.
Iowa to Mayo Clinic bus services, operated by Jefferson Lines, depart from Des Moines station.
Iowa to Mayo Clinic bus services, operated by Jefferson Lines, arrive at St. Paul station.
Yes, the driving distance between Iowa to Mayo Clinic is 209 miles. It takes approximately 3h 28m to drive from Iowa to Mayo Clinic.
There are 53+ hotels available in Mayo Clinic.
What companies run services between Iowa, USA and Mayo Clinic, MN, USA?
You can take a bus from Des Moines to Mayo Clinic via St. Paul and Rochester in around 7h 13m.
- Website
- delta.com
Flights from Des Moines to Minneapolis–Saint Paul International Airport
- Ave. Duration
- 1h 14m
- When
- Every day
- Estimated price
- $55–390
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Des Moines to St. Paul
- Ave. Duration
- 4h 40m
- Frequency
- Twice daily
- Estimated price
- $60–90
- Book at
- Jefferson Lines
- Adult
- $60–90
Bus from St. Paul to Rochester
- Ave. Duration
- 1h 25m
- Frequency
- Once daily
- Estimated price
- $28–40
- Book at
- Jefferson Lines
- Adult
- $28–40
Bus from Des Moines to St. Paul
- Ave. Duration
- 4h 40m
- Frequency
- Twice daily
- Estimated price
- $60–90
- Book at
- Jefferson Lines
- Adult
- $60–90
Bus from Des Moines to Minneapolis
- Ave. Duration
- 5h 45m
- Frequency
- 3 times a day
- Estimated price
- $65–90
- Book at
- Jefferson Lines
- Adult
- $65–90
Bus from Minneapolis to Rochester
- Ave. Duration
- 2h 15m
- Frequency
- Once daily
- Estimated price
- $30–45
- Book at
- Jefferson Lines
- Adult
- $30–45
Bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochester
- Ave. Duration
- 1h 45m
- Frequency
- Every 4 hours
- Estimated price
- $40–50
- Website
- Groome Transportation - Rochester - MSP
Bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochester
- Ave. Duration
- 1h 45m
- Frequency
- Every 4 hours
- Estimated price
- $40–50
- Website
- Groome Transportation - Rochester - MSP
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide