Rome2Rio

How to get fromIowa to Mayo Clinicby bus, shuttle, car, or plane

Find Transport to Mayo Clinic

See all options

There are 5 ways to get from Iowa to Mayo Clinic by bus, shuttle, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, shuttle

    best
    1. Take the bus from Des Moines to Owatonnabus bus Jefferson 802 / ...
    2. Take a shuttle bus from Owatonna, MN to Rochestershuttle bus S MN Conn
    5h 36m
    $64–120

  2. Drive 207.6 mi

    cheapest
    1. Drive from Des Moines to Mayo Cliniccar car 207.6 mi
    3h 28m
    $38–55

  3. Fly, bus

    1. Fly from Des Moines (DSM) to Minneapolis–Saint Paul International Airport (MSP)plane plane DSM - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    4h 15m
    $150–623

  4. Bus

    1. Take the bus from Des Moines to St. Paulbus bus Jefferson 802
    2. Take the bus from St. Paul to Rochester, MNbus bus Minneapolis / ...
    7h 33m
    $102–140

  5. Bus via Richfield

    1. Take the bus from Des Moines to MSP Airportbus bus Jefferson 802
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus Groome Transportation
    7h 36m
    $121–152

Des Moines (DSM) to Minneapolis–Saint Paul International Airport (MSP) flights

Calendar27Weekly Planes
Duration1h 14mAverage Duration
Ticket$83Cheapest Price
See schedules

Questions & Answers

Map of how to get from Iowa to Mayo Clinic.ExpandLaunch map view
  • Distance: 229.7 mi
  • Duration: 5h 36m

What companies run services between Iowa, USA and Mayo Clinic, MN, USA?

You can take a vehicle from Des Moines to Mayo Clinic via Des Moines, St. Paul, and Rochester in around 7h 33m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides