There are 6 ways to get from Iowa to Mississippi by plane, bus (Greyhound), bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Des Moines
best- Fly from Des Moines (DSM) to Memphis (MEM)plane DSM - MEM
4h 39m$210–948Fly from Quad City International Airport
cheapest- Fly from Quad City International Airport (MLI) to Memphis (MEM)plane MLI - MEM
6h 37m$144–729Bus
- Take the bus from Des Moines to Kansas Citybus
- Take the bus from Kansas City Bus Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Jacksonbus
21h 15m$158–282Bus, train
- Take the bus from Des Moines to Champaign Intermodal Trans Ctrbus Greyhound US0157S
- Take the train from Champaign-Urbana to Jacksontrain City of New Orleans
21h 15m$214–475Drive 803.6 mi
- Drive from Des Moines to Jacksoncar 803.6 mi
14h 17m$147–212Fly from Omaha
- Fly from Omaha (OMA) to Memphis (MEM)plane OMA - MEM
7h 1m$195–930
Iowa to Mississippi by bus
Questions & Answers
The cheapest way to get from Iowa to Mississippi is to drive which costs $140 - $220 and takes 14h 17m.
The fastest way to get from Iowa to Mississippi is to fly which takes 4h 39m and costs $210 - $950.
No, there is no direct bus from Iowa to Mississippi. However, there are services departing from Des Moines and arriving at Jackson via Kansas City Bus Station and St Louis Bus Station. The journey, including transfers, takes approximately 21h 15m.
The distance between Iowa and Mississippi is 507 miles. The road distance is 808.3 miles.
The best way to get from Iowa to Mississippi without a car is to bus which takes 21h 15m and costs $150 - $290.
It takes approximately 4h 39m to get from Iowa to Mississippi, including transfers.
Iowa to Mississippi bus services, operated by Jefferson Lines, depart from Des Moines station.
The best way to get from Iowa to Mississippi is to fly which takes 4h 39m and costs $210 - $950. Alternatively, you can bus, which costs $150 - $290 and takes 21h 15m.
Iowa to Mississippi bus services, operated by Jefferson Lines, arrive at Kansas City station.
Yes, the driving distance between Iowa to Mississippi is 808 miles. It takes approximately 14h 17m to drive from Iowa to Mississippi.
What companies run services between Iowa, USA and Mississippi, USA?
Delta, United Airlines, and two other airlines fly from Des Moines (DSM) to Memphis (MEM) hourly. Alternatively, you can take a bus from Des Moines to Jackson via Kansas City, Kansas City Bus Station, and St Louis Bus Station in around 21h 15m.
- Website
- delta.com
Flights from Des Moines to Memphis via Atlanta
- Ave. Duration
- 4h 59m
- When
- Every day
- Estimated price
- $210–1,100
Flights from Des Moines to Memphis via Detroit
- Ave. Duration
- 6h 40m
- When
- Every day
- Estimated price
- $220–1,100
Flights from Des Moines to Memphis via Minneapolis
- Ave. Duration
- 7h 17m
- When
- Every day
- Estimated price
- $190–1,000
Flights from Quad City International Airport to Memphis via Atlanta
- Ave. Duration
- 4h 48m
- When
- Every day
- Estimated price
- $160–800
Flights from Omaha to Memphis via Atlanta
- Ave. Duration
- 5h
- When
- Every day
- Estimated price
- $220–1,100
Flights from Omaha to Memphis via Minneapolis
- Ave. Duration
- 5h 36m
- When
- Every day
- Estimated price
- $200–1,000
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Champaign-Urbana to Jackson
- Ave. Duration
- 12h 45m
- Frequency
- Once daily
- Estimated price
- $160–370
- Website
- Amtrak
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Des Moines to Kansas City
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
Want to know more about travelling around United States
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More Questions & Answers
There are 225+ hotels available in Mississippi.






