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How to get fromIowa to Saint Charlesby bus, plane, bus (Greyhound), train, or car

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There are 6 ways to get from Iowa to Saint Charles by bus, plane, bus (Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 41 bus to Omaha, fly, line 34 bus

    best
    1. Take the bus from 1st Ave & 8th St NE to 11th & Dodge NEbus bus
    2. Fly from Omaha (OMA) to Lambert–St. Louis International Airport (STL)plane plane OMA - STL
    3. Take the bus from North Hanley Transit Center to 4375 Rider Trail North Sbbus bus
    5h 7m
    $607–907

  2. Drive  310.1 mi

    cheapest
    1. Drive from Des Moines to Saint Charlescar car 310.1 mi
    6h 19m
    $57–82

  3. Bus

    1. Take the bus from Des Moines to Kansas Citybus bus Jefferson Lines 803 / ...
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus Greyhound US0180s / ...
    9h 55m
    $92–146

  4. Bus, train via Kansas City

    1. Take the bus from Des Moines to Kansas Citybus bus Jefferson Lines 803 / ...
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    12h 15m
    $127–246

  5. Fly from Quad City International Airport

    1. Fly from Quad City International Airport (MLI) to Lambert–St. Louis International Airport (STL)plane plane MLI - STL
    6h 50m
    $76–456

  6. Bus, train

    1. Take the bus from Des Moines to Bloomington-Normalbus bus Greyhound US0157S
    2. Take the train from Bloomington-Normal to St. Louistrain train Lincoln Service / ...
    11h 36m
    $93–189

Iowa to Saint Charles by bus and train

Calendar18Weekly Services
Duration9h 55mAverage Duration
Ticket$92Cheapest Price
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Questions & Answers

Map of how to get from Iowa to Saint Charles.ExpandLaunch map view
  • Distance: 365.7 mi
  • Duration: 5h 7m

What companies run services between Iowa, USA and Saint Charles, MO, USA?

You can take a bus from Des Moines to 4375 Rider Trail North Sb via Kansas City, Kansas City Bus Station, St Louis Bus Station, CIVIC CENTER station, NORTH HANLEY station, and North Hanley Transit Center in around 9h 55m. Alternatively, United Airlines, American Airlines, and Delta fly from Quad City International Airport (MLI) to Lambert–St. Louis International Airport (STL) hourly.

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