There are 7 ways to get from Iowa to San Antonio by plane, bus (Flixbus), car, bus, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Des Moines to San Antonio International Airport
best- Fly from Des Moines (DSM) to San Antonio International Airport (SAT)plane DSM - SAT
5h 20m$171–825Fly Quad City International Airport to San Antonio International Airport
cheapest- Fly from Quad City International Airport (MLI) to San Antonio International Airport (SAT)plane MLI - SAT
7h 37m$134–654Bus via Denton
- Take the bus from Des Moines to Kansas Citybus
- Take the bus from Kansas City Bus Station to Dentonbus
- Take the bus from Denton to San Antonio Bus Stationbus
22h 20m$178–267Drive 953.1 mi
- Drive from Des Moines to San Antoniocar 953.1 mi
15h 57m$174–252Fly Des Moines to Austin-Bergstrom International Airport, bus
- Fly from Des Moines (DSM) to Austin-Bergstrom International Airport (AUS)plane DSM - AUS
- Take the bus from Austin, TX - UT Austin to San Antonio, TX - E Commerce Stbus
6h$170–754Fly Omaha to San Antonio International Airport
- Fly from Omaha (OMA) to San Antonio International Airport (SAT)plane OMA - SAT
7h 47m$145–755Bus
- Take the bus from Des Moines to Omaha, NEbus Greyhound US0123S
- Take the bus from Omaha to San Antoniobus Omaha-Aguascalientes
25h 46m$270–287
Iowa to San Antonio by bus
Comparing Your Travel Options
The cheapest way to get from Iowa to San Antonio is to drive which costs $170 - $260 and takes 15h 57m.
The fastest way to get from Iowa to San Antonio is to fly which takes 5h 20m and costs $170 - $850.
No, there is no direct bus from Iowa to San Antonio station. However, there are services departing from Des Moines and arriving at San Antonio Bus Station via Kansas City Bus Station and Denton. The journey, including transfers, takes approximately 22h 20m.
The distance between Iowa and San Antonio is 893 miles. The road distance is 958.7 miles.
The best way to get from Iowa to San Antonio without a car is to bus via Denton which takes 22h 20m and costs $170 - $270.
It takes approximately 5h 20m to get from Iowa to San Antonio, including transfers.
Iowa to San Antonio bus services, operated by Jefferson Lines, depart from Des Moines station.
The best way to get from Iowa to San Antonio is to fly which takes 5h 20m and costs $170 - $850. Alternatively, you can bus via Denton, which costs $170 - $270 and takes 22h 20m.
Iowa to San Antonio bus services, operated by Jefferson Lines, arrive at Kansas City station.
Yes, the driving distance between Iowa to San Antonio is 959 miles. It takes approximately 15h 57m to drive from Iowa to San Antonio.
What companies run services between Iowa, USA and San Antonio, TX, USA?
American Airlines, United Airlines, and two other airlines fly from Des Moines (DSM) to San Antonio International Airport (SAT) hourly. Alternatively, you can take a bus from Des Moines to San Antonio Bus Station via Kansas City, Kansas City Bus Station, and Denton in around 22h 20m.
- Website
- aa.com
Flights from Des Moines to San Antonio International Airport via Dallas/Ft.Worth
- Ave. Duration
- 4h 40m
- When
- Every day
- Estimated price
- $150–800
Flights from Des Moines to San Antonio International Airport via Chicago O'Hare
- Ave. Duration
- 7h 12m
- When
- Every day
- Estimated price
- $210–1,000
Flights from Des Moines to Austin-Bergstrom International Airport via Dallas/Ft.Worth
- Ave. Duration
- 4h 22m
- When
- Every day
- Estimated price
- $130–700
Flights from Quad City International Airport to San Antonio International Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 2m
- When
- Every day
- Estimated price
- $130–650
Flights from Quad City International Airport to San Antonio International Airport via Charlotte
- Ave. Duration
- 6h 26m
- When
- Every day
- Estimated price
- $200–900
Flights from Quad City International Airport to San Antonio International Airport via Chicago O'Hare
- Ave. Duration
- 6h 36m
- When
- Every day
- Estimated price
- $150–750
Flights from Omaha to San Antonio International Airport via Dallas/Ft.Worth
- Ave. Duration
- 4h 48m
- When
- Every day
- Estimated price
- $140–750
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Des Moines to Kansas City
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Booking & Getting There
There are 1331+ hotels available in San Antonio.



