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How to get fromIowa to South Carolinaby plane, taxi, bus, train, or car

Find Transport to South Carolina

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There are 6 ways to get from Iowa to South Carolina by plane, taxi, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Des Moines to Charlotte Douglas International Airport, taxi

    best
    1. Fly from Des Moines (DSM) to Charlotte Douglas International Airport (CLT)plane plane DSM - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    3h 6m
    $219–823

  2. Fly Quad City International Airport to Greenville–Spartanburg International Airport

    cheapest
    1. Fly from Quad City International Airport (MLI) to Greenville–Spartanburg International Airport (GSP)plane plane MLI - GSP
    6h 39m
    $157–697

  3. Bus, train

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    4. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train
    38h 10m
    $858–1,355

  4. Drive  1,158.9 mi

    1. Drive from Des Moines to Charlestoncar car 1,158.9 mi
    20h 40m
    $212–306

  5. Fly Quad City International Airport to Charlotte Douglas International Airport, taxi

    1. Fly from Quad City International Airport (MLI) to Charlotte Douglas International Airport (CLT)plane plane MLI - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    5h 7m
    $192–752

  6. Bus, train, taxi

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the train from Kansas City to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Savannah Stationtrain train
    4. Take the taxi from Savannah Station to Bluffton Transfer Centertaxi taxi
    5. Take the bus from Bluffton Transfer Center to Walmartbus bus 320
    6. Take the taxi from Walmart to Dorchester Village Shopping Center Park & Ridetaxi taxi
    2d 3h

Des Moines (DSM) to Charlotte Douglas International Airport (CLT) flights

Calendar65Weekly Planes
Duration4h 6mAverage Duration
Ticket$127Cheapest Price
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Comparing Your Travel Options

Map of how to get from Iowa to South Carolina.ExpandLaunch map view
  • Distance: 848 mi
  • Duration: 3h 6m

What companies run services between Iowa, USA and South Carolina, USA?

American Airlines, United Airlines, and two other airlines fly from Quad City International Airport (MLI) to Greenville–Spartanburg International Airport (GSP) every 2 hours.

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