There are 6 ways to get from Iowa to Tupelo by plane, car, bus (Greyhound, Flixbus), bus (Greyhound, Amtrak, Flixbus), bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Quad City International Airport to Golden Triangle Regional Airport, drive
best- Fly from Quad City International Airport (MLI) to Golden Triangle Regional Airport (GTR)plane MLI - GTR
- Drive from Golden Triangle Regional Airport (GTR) to Tupelocar
8h 20m$93–449Bus via Kansas City
- Take the bus from Des Moines to Kansas Citybus
- Take the bus from Kansas City Bus Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
17h 49m$166–263Drive 681.7 mi
- Drive from Des Moines to Tupelocar 681.7 mi
12h 45m$125–180Fly Des Moines to Tupelo Regional Airport
- Fly from Des Moines (DSM) to Tupelo Regional Airport (TUP)plane DSM - TUP
3h 59m$128–591Bus
- Take the bus from Des Moines to Galesburgbus
- Take the bus from Galesburg Amtrak Station to Springfieldbus
- Take the bus from Springfield SMTD Transfer Center to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
18h 51mBus, train
- Take the bus from Des Moines to Kansas Citybus
- Take the train from Kansas City to St. Louistrain
- Take the bus from St Louis Bus Station to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
20h 9m$276–433
Quad City International Airport (MLI) to Golden Triangle Regional Airport (GTR) flights
Comparing Your Travel Options
The cheapest way to get from Iowa to Tupelo is to drive which costs $120 - $180 and takes 12h 45m.
The fastest way to get from Iowa to Tupelo is to fly which takes 3h 59m and costs $120 - $600.
No, there is no direct bus from Iowa to Tupelo. However, there are services departing from Des Moines and arriving at Tupelo via Kansas City Bus Station, St Louis Bus Station and Memphis Bus Station. The journey, including transfers, takes approximately 17h 49m.
The distance between Iowa and Tupelo is 641 miles. The road distance is 685.6 miles.
The best way to get from Iowa to Tupelo without a car is to bus via Kansas City which takes 17h 49m and costs $160 - $270.
It takes approximately 8h 20m to get from Iowa to Tupelo, including transfers.
Iowa to Tupelo bus services, operated by Jefferson Lines, depart from Des Moines station.
The best way to get from Iowa to Tupelo is to bus via Kansas City which takes 17h 49m and costs $160 - $270. Alternatively, you can fly, which costs $120 - $600 and takes 3h 59m.
Iowa to Tupelo bus services, operated by Jefferson Lines, arrive at Kansas City station.
Yes, the driving distance between Iowa to Tupelo is 686 miles. It takes approximately 12h 45m to drive from Iowa to Tupelo.
What companies run services between Iowa, USA and Tupelo, MS, USA?
You can take a bus from Des Moines to Tupelo via Kansas City, Kansas City Bus Station, St Louis Bus Station, Memphis Bus Station, and Tupelo in around 17h 49m. Alternatively, Allegiant Air, Corporate Flight Management Inc, and four other airlines fly from Des Moines (DSM) to Tupelo Regional Airport (TUP) twice daily.
- Website
- contouraviation.com
Flights from Des Moines to Tupelo Regional Airport via Nashville
- Ave. Duration
- 3h 48m
- When
- Monday and Sunday
- Estimated price
- $95–550
Flights from Des Moines to Tupelo Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 4h 45m
- When
- Sunday
- Estimated price
- $120–650
Flights from Des Moines to Tupelo Regional Airport via Atlanta, Nashville
- Ave. Duration
- 6h 56m
- When
- Every day
- Estimated price
- $130–650
Flights from Des Moines to Tupelo Regional Airport via Chicago Midway, Nashville
- Ave. Duration
- 6h 45m
- When
- Monday, Thursday, and Friday
- Estimated price
- $110–600
Flights from Des Moines to Tupelo Regional Airport via Chicago O'Hare, Nashville
- Ave. Duration
- 7h 23m
- When
- Sunday
- Estimated price
- $110–600
- Website
- delta.com
Flights from Quad City International Airport to Golden Triangle Regional Airport via Atlanta
- Ave. Duration
- 6h 19m
- When
- Every day
- Estimated price
- $80–430
- Website
- aa.com
Flights from Quad City International Airport to Golden Triangle Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 8h 29m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $100–490
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Kansas City to St. Louis
- Ave. Duration
- 5h 40m
- Frequency
- Twice daily
- Estimated price
- $150–240
- Website
- Amtrak
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Des Moines to Kansas City
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
Bus from Des Moines to Kansas City
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Kansas City Bus Station to St Louis Bus Station
- Ave. Duration
- 4h
- Frequency
- 4 times a day
- Estimated price
- $40–70
- Website
- Greyhound
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $50–80
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $17–27
- Website
- Greyhound
Bus from Des Moines to Galesburg
- Ave. Duration
- 4h 30m
- Frequency
- Once daily
- Estimated price
- $35–55
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $17–27
- Website
- Greyhound
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $50–80
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $17–27
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- 5 times a week
- Estimated price
- $45–70
- Schedules at
- Flixbus USA
Bus from Springfield SMTD Transfer Center to Memphis Bus Station
- Ave. Duration
- 6h 50m
- Frequency
- 5 times a week
- Estimated price
- $60–95
- Schedules at
- Flixbus USA
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- 5 times a week
- Estimated price
- $45–70
- Schedules at
- Flixbus USA
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Galesburg Amtrak Station to Springfield
- Ave. Duration
- 2h 15m
- Frequency
- Once daily
- Website
- Amtrak
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Booking & Getting There
There are 26+ hotels available in Tupelo.











