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How to get fromIowa to West Lafayetteby bus (Greyhound, Amtrak), bus, train, car, plane, bus (Greyhound), or shuttle

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There are 8 ways to get from Iowa to West Lafayette by bus (Greyhound, Amtrak), bus, train, car, plane, bus (Greyhound), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Chicago

    best
    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the bus from Chicago Union Station to Lafayette Amtrak Stationbus bus Chicago
    10h 39m
    $91–145

  2. Fly Quad City International Airport to Purdue University Airport

    cheapest
    1. Fly from Quad City International Airport (MLI) to Purdue University Airport (LAF)plane plane MLI - LAF
    7h 31m
    $48–323

  3. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    12h 31m
    $193–315

  4. Drive  410.2 mi

    1. Drive from Des Moines to West Lafayettecar car 410.2 mi
    7h 25m
    $68–98

  5. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train Cardinal
    11h 20m
    $133–210

  6. Bus (Greyhound)

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus Greyhound US0157S
    2. Take the bus from Indianapolis Union Station to Lafayette Bus Stopbus bus Greyhound US0100 / ...
    11h 45m
    $99–157

  7. Fly Des Moines to Chicago Midway International Airport, train

    1. Fly from Des Moines (DSM) to Chicago Midway International Airport (MDW)plane plane DSM - MDW
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    6h 24m
    $141–498

  8. Fly Quad City International Airport to Chicago O'Hare International Airport, shuttle

    1. Fly from Quad City International Airport (MLI) to Chicago O'Hare International Airport (ORD)plane plane MLI - ORD
    2. Take a shuttle bus from O'Hare International Terminal 2 to West Lafayette, INshuttle bus
    8h 9m
    $63–293

Quad City International Airport (MLI) to Purdue University Airport (LAF) flights

Calendar16Weekly Planes
Duration6h 14mAverage Duration
Ticket$47Cheapest Price
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Comparing Your Travel Options

Map of how to get from Iowa to West Lafayette.ExpandLaunch map view
  • Distance: 463.1 mi
  • Duration: 10h 39m

What companies run services between Iowa, USA and West Lafayette, IN, USA?

You can take a vehicle from Des Moines to Lafayette Amtrak Station via Des Moines, Chicago Bus Station, and Chicago Union Station in around 10h 39m. Alternatively, United Airlines and American Airlines fly from Quad City International Airport (MLI) to Purdue University Airport (LAF) twice daily.

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Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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Need to know: Greyhound

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