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How to get fromIowa to Winston-Salemby plane, bus (Greyhound), bus, train, or car

Find Transport to Winston-Salem

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There are 10 ways to get from Iowa to Winston-Salem by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Des Moines to Piedmont Triad International Airport

    best
    1. Fly from Des Moines (DSM) to Piedmont Triad International Airport (GSO)plane plane DSM - GSO
    5h 37m
    $298–1,446

  2. Fly Quad City International Airport to Charlotte Douglas International Airport, bus

    cheapest
    1. Fly from Quad City International Airport (MLI) to Charlotte Douglas International Airport (CLT)plane plane MLI - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    7h 41m
    $118–628

  3. Bus (Greyhound)

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Columbusbus bus
    3. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    25h 55m
    $177–290

  4. Bus, train

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Charlottesvilletrain train
    3. Take the train from Charlottesville to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Winston Salem(Trans Center)bus bus
    31h 58m
    $292–687

  5. Drive  976.3 mi

    1. Drive from Des Moines to Winston-Salemcar car 976.3 mi
    16h 56m
    $179–258

  6. Fly Des Moines to Charlotte Douglas International Airport, bus

    1. Fly from Des Moines (DSM) to Charlotte Douglas International Airport (CLT)plane plane DSM - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    5h 40m
    $205–949

  7. Fly Quad City International Airport to Piedmont Triad International Airport

    1. Fly from Quad City International Airport (MLI) to Piedmont Triad International Airport (GSO)plane plane MLI - GSO
    7h 24m
    $171–875

  8. Bus via Chicago

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago to Columbusbus bus
    3. Take the bus from Wilson & Ferrell Shell Station - Columbus to Winston Salem(Trans Center)bus bus
    26h 25m
    $153–280

  9. Bus, train via Chicago

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to High Pointtrain train
    37h 7m
    $375–915

  10. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Greensborotrain train
    5. Take the bus from Greensboro Bus Stop to Winston Salem(Trans Center)bus bus
    37h 39m
    $394–1,002

Des Moines (DSM) to Piedmont Triad International Airport (GSO) flights

Calendar82Weekly Planes
Duration6h 12mAverage Duration
Ticket$259Cheapest Price
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Comparing Your Travel Options

Map of how to get from Iowa to Winston-Salem.ExpandLaunch map view
  • Distance: 856.4 mi
  • Duration: 5h 37m

What companies run services between Iowa, USA and Winston-Salem, NC, USA?

Delta, United Airlines, and American Airlines fly from Des Moines (DSM) to Piedmont Triad International Airport (GSO) every 2 hours. Alternatively, you can take a vehicle from Des Moines to Winston Salem(Trans Center) via Des Moines, Indianapolis Union Station, and Columbus in around 25h 55m.

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Need to know: Greyhound

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