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How to get fromIowa to Winston-Salemby plane, bus, train, or car

Find Transport to Winston-Salem

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There are 9 ways to get from Iowa to Winston-Salem by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Des Moines to Charlotte Douglas International Airport, bus

    best
    1. Fly from Des Moines (DSM) to Charlotte Douglas International Airport (CLT)plane plane DSM - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    5h 45m
    $169–817

  2. Fly Quad City International Airport to Charlotte Douglas International Airport, bus

    cheapest
    1. Fly from Quad City International Airport (MLI) to Charlotte Douglas International Airport (CLT)plane plane MLI - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    7h 47m
    $113–598

  3. Bus, train

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Ashland Amtrak Stationtrain train
    3. Take the bus from Ashland Bus Station to Winston Salem(Trans Center)bus bus
    25h 20m
    $189–390

  4. Drive 976.3 mi

    1. Drive from Des Moines to Winston-Salemcar car 976.3 mi
    16h 56m
    $179–258

  5. Fly Quad City International Airport to Piedmont Triad International Airport

    1. Fly from Quad City International Airport (MLI) to Piedmont Triad International Airport (GSO)plane plane MLI - GSO
    7h 36m
    $151–725

  6. Bus to The Eastern Iowa Airport, fly to Piedmont Triad International Airport

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Piedmont Triad International Airport (GSO)plane plane CID - GSO
    8h 59m

  7. Fly Omaha to Charlotte Douglas International Airport, bus

    1. Fly from Omaha (OMA) to Charlotte Douglas International Airport (CLT)plane plane OMA - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    8h 33m
    $164–849

  8. Bus to Chicago O'Hare International Airport, fly to Piedmont Triad International Airport

    1. Take the bus from Davenport to Chicago Bus Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Piedmont Triad International Airport (GSO)plane plane ORD - GSO
    9h 46m
    $147–676

  9. Bus to The Eastern Iowa Airport, fly to Charlotte Douglas International Airport, bus

    1. Take the bus from Court St Transportation Center to GTC Bay 9bus bus
    2. Fly from The Eastern Iowa Airport (CID) to Charlotte Douglas International Airport (CLT)plane plane CID - CLT
    3. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    8h 42m

Des Moines (DSM) to Charlotte Douglas International Airport (CLT) flights

Calendar80Weekly Planes
Duration4h 36mAverage Duration
Ticket$148Cheapest Price
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Questions & Answers

Map of how to get from Iowa to Winston-Salem.ExpandLaunch map view
  • Distance: 905 mi
  • Duration: 5h 45m

What companies run services between Iowa, USA and Winston-Salem, NC, USA?

American Airlines, Delta, and United Airlines fly from Quad City International Airport (MLI) to Piedmont Triad International Airport (GSO) every 3 hours.

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