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How to get fromIrvine to Knoxvilleby plane, train, bus, bus (Greyhound, Flixbus), or car

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There are 11 ways to get from Irvine to Knoxville by plane, train, bus, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly John Wayne Airport Orange County to Mcghee Tyson Airport

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Mcghee Tyson Airport (TYS)plane plane SNA - TYS
    7h 47m
    $407–1,572

  2. Train to Los Angeles International Airport, fly to Nashville, drive

    cheapest
    1. Take the train from Tustin to L.A. Union Stationtrain train
    2. Fly from Los Angeles International Airport (LAX) to Nashville (BNA)plane plane LAX - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    9h 32m
    $225–380

  3. Train, bus

    1. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus
    3d 6h
    $1,845–2,922

  4. Bus

    1. Take the bus from Anaheim Regional Transportation Intermodal Center to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    4. Take the bus from New York to Knoxvillebus bus
    3d 11h
    $722–1,097

  5. Drive  2,166.1 mi

    1. Drive from Irvine to Knoxvillecar car 2,166.1 mi
    34h 18m
    $371–535

  6. Train to Los Angeles International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Tustin to L.A. Union Stationtrain train
    2. Fly from Los Angeles International Airport (LAX) to Mcghee Tyson Airport (TYS)plane plane LAX - TYS
    9h 6m
    $331–1,295

  7. Train to Ontario International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Tustin to Riverside - Downtowntrain train
    2. Fly from Ontario International Airport (ONT) to Mcghee Tyson Airport (TYS)plane plane ONT - TYS
    9h 38m
    $426–1,684

  8. Train to Burbank Bob Hope Airport, fly to Mcghee Tyson Airport

    1. Take the train from Tustin to L.A. Union Stationtrain train
    2. Fly from Burbank Bob Hope Airport (BUR) to Mcghee Tyson Airport (TYS)plane plane BUR - TYS
    9h 25m
    $380–1,492

  9. Fly Long Beach Airport to Mcghee Tyson Airport

    1. Fly from Long Beach Airport (LGB) to Mcghee Tyson Airport (TYS)plane plane LGB - TYS
    10h 1m
    $565–2,384

  10. Fly John Wayne Airport Orange County to Hartsfield-Jackson Atlanta International Airport, drive

    1. Fly from John Wayne Airport Orange County (SNA) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane SNA - ATL
    2. Drive from Atlanta-Airport-ATL to Knoxvillecar car
    9h 21m
    $487–707

  11. Train, bus via Farragut

    1. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus
    3d 8h
    $1,891–3,014

John Wayne Airport Orange County (SNA) to Mcghee Tyson Airport (TYS) flights

Calendar60Weekly Planes
Duration7h 8mAverage Duration
Ticket$352Cheapest Price
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Comparing Your Travel Options

Map of how to get from Irvine to Knoxville.ExpandLaunch map view
  • Distance: 1,934.4 mi
  • Duration: 7h 47m

What companies run services between Irvine, CA, USA and Knoxville, TN, USA?

American Airlines, United Airlines, and two other airlines fly from John Wayne Airport Orange County (SNA) to Mcghee Tyson Airport (TYS) every 3 hours. Alternatively, you can take a bus from Main-Harvard to Knoxville via Artic - Dock 4, Anaheim Regional Transportation Intermodal Center, Los Angeles Union Station, St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 3d 11h.

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