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How to get fromIrvine to Knoxvilleby plane, train, bus, bus (Greyhound), or car

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There are 6 ways to get from Irvine to Knoxville by plane, train, bus, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Mcghee Tyson Airport (TYS)plane plane SNA - TYS
    6h 17m
    $354–1,004

  2. Train to Los Angeles International Airport, fly

    cheapest
    1. Take the train from Tustin to L.A. Union Stationtrain train
    2. Fly from Los Angeles International Airport (LAX) to Mcghee Tyson Airport (TYS)plane plane LAX - TYS
    9h 31m
    $341–1,195

  3. Train, bus

    1. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus
    3d 6h
    $1,155–2,322

  4. Bus

    1. Take the bus from Anaheim to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    4. Take the bus from New York to Knoxvillebus bus
    3d 11h
    $673–1,188

  5. Drive 2,166.1 mi

    1. Drive from Irvine to Knoxvillecar car 2,166.1 mi
    34h 19m
    $396–571

  6. Train, bus via Farragut

    1. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus
    3d 8h
    $1,201–2,414

John Wayne Airport Orange County (SNA) to Mcghee Tyson Airport (TYS) flights

Calendar57Weekly Planes
Duration6h 53mAverage Duration
Ticket$299Cheapest Price
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Questions & Answers

Map of how to get from Irvine to Knoxville.ExpandLaunch map view
  • Distance: 1,931.8 mi
  • Duration: 6h 17m

What companies run services between Irvine, CA, USA and Knoxville, TN, USA?

Southwest Airlines, United Airlines, and three other airlines fly from John Wayne Airport Orange County (SNA) to Mcghee Tyson Airport (TYS) every 4 hours. Alternatively, you can take a bus from Main-Harvard to Knoxville via Artic - Dock 4, Anaheim, Los Angeles Union Station, St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 3d 11h.

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