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How to get fromIrvine to Louisvilleby plane, bus (Greyhound, Flixbus), train, bus, or car

Find Transport to Louisville

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There are 6 ways to get from Irvine to Louisville by plane, bus (Greyhound, Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from John Wayne Airport Orange County

    best
    1. Fly from John Wayne Airport Orange County (SNA) to Louisville International Airport (SDF)plane plane SNA - SDF
    7h 6m
    $235–1,001

  2. Train to Los Angeles International Airport, fly

    cheapest
    1. Take the train from Tustin to L.A. Union Stationtrain train
    2. Fly from Los Angeles International Airport (LAX) to Louisville International Airport (SDF)plane plane LAX - SDF
    9h 55m
    $197–828

  3. Bus

    1. Take the bus from Anaheim Regional Transportation Intermodal Center to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    4. Take the bus from Evansville, IN to Louisville, KYbus bus
    2d 4h
    $414–739

  4. Train, bus via Chicago (Amtrak)

    1. Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    2d 4h
    $1,329–2,124

  5. Drive  2,066.9 mi

    1. Drive from Irvine to Louisvillecar car 2,066.9 mi
    33h 1m
    $378–545

  6. Train, bus

    1. Take the train from Pomona Amtrak to St. Louistrain train
    2. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    3. Take the bus from Evansville, IN to Louisville, KYbus bus
    2d 18h
    $1,368–2,283

Irvine to Louisville by bus

Calendar7Weekly Buses
Duration2d 4hAverage Duration
Ticket$414Cheapest Price
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Comparing Your Travel Options

Map of how to get from Irvine to Louisville.ExpandLaunch map view
  • Distance: 1,820.4 mi
  • Duration: 7h 6m

What companies run services between Irvine, CA, USA and Louisville, KY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from John Wayne Airport Orange County (SNA) to Louisville International Airport (SDF) every 2 hours. Alternatively, you can take a bus from Main-Harvard to Louisville, KY via Artic - Dock 4, Anaheim Regional Transportation Intermodal Center, Los Angeles Union Station, St Louis Bus Station, and Evansville, IN in around 2d 4h.

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