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How to get fromIrvine to Otay Mesaby train, tram, bus (Flixbus, Greyhound), car, or bus (Greyhound)

Find Transport to Otay Mesa

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There are 4 ways to get from Irvine to Otay Mesa by train, tram, bus (Flixbus, Greyhound), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, tram

    best
    1. Take the train from Irvine to San Diego Old Town Transportation Centertrain train Pacific Surfliner
    2. Take the tram from Old Town Station to Iris Avenue Stationtram tram Blue
    4h 6m
    $35–80

  2. Drive 99.2 mi

    cheapest
    1. Drive from Irvine to Otay Mesacar car 99.2 mi
    1h 45m
    $19–27

  3. Line 59 bus, bus

    1. Take the bus from University-Ent 3773 Mariposa Villa to The Depot At Santa Ana Dock 3bus bus 59
    2. Take the bus from Santa Ana to San Ysidrobus bus Lxus 3105 / ...
    4h 22m
    $23–47

  4. Bus, line 929 bus

    1. Take the bus from Santa Ana to San Diegobus bus Los Angeles
    2. Take the bus from 12th & Imperial Transit Center to Iris Avenue Transit Centerbus bus 929 / ...
    5h 10m
    $24–40

Irvine to Otay Mesa by train, tram, and bus

Calendar91Weekly Services
Duration4h 6mAverage Duration
Ticket$35Cheapest Price
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Questions & Answers

Map of how to get from Irvine to Otay Mesa.ExpandLaunch map view
  • Distance: 106.1 mi
  • Duration: 4h 6m

What companies run services between Irvine, CA, USA and Otay Mesa, CA, USA?

You can take a bus from University-Ent 3773 Mariposa Villa to Otay Mesa Rd & Cactus Rd via The Depot At Santa Ana Dock 3, Santa Ana, San Ysidro, San Ysidro Transit Center, and Iris Avenue Transit Center in around 4h 22m.

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Bus operators

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