There are 3 ways to get from Irvine to Santee by train, tram, bus (Greyhound, Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train, tram
best- Take the train from Irvine to San Diego Old Town Transportation Centertrain Pacific Surfliner
- Take the tram from Old Town Station to El Cajon Stationtram Green
3h 51m$29–88Drive 86.3 mi
cheapest- Drive from Irvine to Santeecar 86.3 mi
1h 31m$16–23Line 53 bus, bus
- Take the bus from Main-Harvard to Artic - Dock 4bus 53
- Take the bus from Anaheim Regional Transportation Intermodal Center to San Diego Greyhound Bus Stopbus Greyhound US0901 / ...
5h 15m$17–28
Irvine to Santee by train and tram
Comparing Your Travel Options
The cheapest way to get from Irvine to Santee is to drive which costs $15 - $23 and takes 1h 31m.
The fastest way to get from Irvine to Santee is to drive which takes 1h 31m and costs $15 - $23.
No, there is no direct bus from Irvine to Santee. However, there are services departing from Main-Harvard and arriving at El Cajon Transit Center via Anaheim Regional Transportation Intermodal Center and San Diego Greyhound Bus Stop. The journey, including transfers, takes approximately 5h 15m.
No, there is no direct train from Irvine to Santee station. However, there are services departing from Tustin and arriving at Santee Town Center Station via Irvine, Old Town Station and El Cajon Station. The journey, including transfers, takes approximately 3h 51m.
The distance between Irvine and Santee is 105 miles. The road distance is 86.8 miles.
The best way to get from Irvine to Santee without a car is to train and tram which takes 3h 51m and costs $29 - $90.
It takes approximately 3h 51m to get from Irvine to Santee, including transfers.
Irvine to Santee bus services, operated by OCTA, depart from Main-Harvard station.
Irvine to Santee train services, operated by Amtrak, depart from Irvine station.
Irvine to Santee bus services, operated by OCTA, arrive at Artic - Dock 4 station.
What companies run services between Irvine, CA, USA and Santee, CA, USA?
You can take a bus from Main-Harvard to Gillespie Field Station via Artic - Dock 4, Anaheim Regional Transportation Intermodal Center, San Diego Greyhound Bus Stop, El Cajon Transit Center, and El Cajon Station in around 5h 15m.
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Irvine to San Diego Old Town Transportation Center
- Ave. Duration
- 1h 40m
- Frequency
- Hourly
- Estimated price
- $19–50
- Website
- Amtrak
- Phone
- +1 714-560-6282
- Website
- octa.net
Bus from Main-Harvard to Artic - Dock 4
- Ave. Duration
- 55 min
- Frequency
- Hourly
- Estimated price
- $2
- Schedules at
- octa.net
- Adult One-way
- $2
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Booking & Getting There
Irvine to Santee train services, operated by Amtrak, arrive at San Diego Old Town Transportation Center station.
Yes, the driving distance between Irvine to Santee is 87 miles. It takes approximately 1h 31m to drive from Irvine to Santee.
There are 1311+ hotels available in Santee.







