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How to get fromIrwin to Chicagoby bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, or bus (Flixbus)

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There are 7 ways to get from Irwin to Chicago by bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 4 bus, bus to Pittsburgh International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Pennsylvania Ave + Main St to Grant St + Liberty Ave FSbus bus
    2. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    3. Fly from Pittsburgh International Airport (PIT) to Chicago Midway International Airport (MDW)plane plane PIT - MDW
    5h 43m

  2. Bus to Johnstown-Cambria County Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from Greensburg Westmoreland Transit Ctr to Johnstown Bus Stopbus bus
    2. Fly from Johnstown-Cambria County Airport (JST) to Chicago O'Hare International Airport (ORD)plane plane JST - ORD
    6h 49m
    $68–322

  3. Train (Amtrak)

    1. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    11h 56m
    $151–326

  4. Bus

    1. Take the bus from Pittsburgh Intermodal Station to Chicago Bus Stationbus bus Greyhound US0164
    12h 15m
    $76–156

  5. Drive 478.6 mi

    1. Drive from Irwin to Chicagocar car 478.6 mi
    7h 55m
    $88–127

  6. Line 4 bus to Pittsburgh International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Pennsylvania Ave + Main St to Grant St + Liberty Ave FSbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Chicago O'Hare International Airport (ORD)plane plane PIT - ORD
    6h 9m
    $383–1,211

  7. Bus via Chicago

    1. Take the bus from Pittsburgh Intermodal Station to Chicagobus bus FlixBus N2640
    13h 32m
    $88–161

Irwin to Chicago by bus and train (Amtrak)

Calendar7Weekly Services
Duration11h 56mAverage Duration
Ticket$151Cheapest Price
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Questions & Answers

Map of how to get from Irwin to Chicago.ExpandLaunch map view
  • Distance: 456.5 mi
  • Duration: 5h 43m

What companies run services between Irwin, PA, USA and Chicago, IL, USA?

Amtrak operates a train from Pittsburgh Amtrak Station to Chicago Union Station once daily. Tickets cost $150–320 and the journey takes 9h 46m. Alternatively, Greyhound USA operates a bus from Pittsburgh Intermodal Station to Chicago Bus Station twice daily. Tickets cost $75–150 and the journey takes 10h 5m. Three other operators also service this route.

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