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How to get fromIsernia to Brusselsby train, plane, train (Trenitalia, Eurostar), bus, car, or car train

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There are 11 ways to get from Isernia to Brussels by train, plane, train (Trenitalia, Eurostar), bus, car, or car train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Fiumicino International Airport, fly to Brussels Airport

    best
    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Brussels Airport (BRU)plane plane FCO - BRU
    7h 31m
    €72–230

  2. Bus, bus to Abruzzo Airport, fly to Brussels South Charleroi Airport, train

    cheapest
    1. Take the bus from Isernia to San Salvo Marinabus bus
    2. Take the bus from San Salvo Marina to Pescara Airportbus bus
    3. Fly from Abruzzo Airport (PSR) to Brussels South Charleroi Airport (CRL)plane plane PSR - CRL
    4. Take the train from Charleroi-Central to Bruxelles-Centraltrain train
    9h 22m
    €61–291

  3. Train

    1. Take the train from Isernia to Roma Terminitrain train Re
    2. Take the train from Roma Termini to Milano Centraletrain train
    3. Take the train from Milano Centrale to Paris Gare De Lyontrain train Fr
    4. Take the train from Paris Nord to Brussel-Zuid / Bruxelles-Miditrain train
    15h 27m
    €238–492

  4. Bus

    1. Take the bus from Isernia to Casello - A1 Ingresso Caianellobus bus 6
    2. Take the bus from Casello - A1 Ingresso Caianello to Bruxelles - Rue du Progrèsbus bus
    22h 42m
    €182–252

  5. Drive  1,580.2 km

    1. Drive from Isernia to Brusselscar car 1,580.2 km
    16h 10m
    €256–370

  6. Train to Naples Airport, fly to Brussels Airport

    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Brussels Airport (BRU)plane plane NAP - BRU
    7h 12m
    €80–243

  7. Train to Roma Ciampino Airport, fly to Brussels South Charleroi Airport, train

    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Roma Ciampino Airport (CIA) to Brussels South Charleroi Airport (CRL)plane plane CIA - CRL
    3. Take the train from Charleroi-Central to Bruxelles-Centraltrain train
    8h 58m
    €103–361

  8. Train to Naples Airport, fly to Brussels South Charleroi Airport, train

    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Brussels South Charleroi Airport (CRL)plane plane NAP - CRL
    3. Take the train from Charleroi-Central to Bruxelles-Centraltrain train
    8h 30m
    €82–329

  9. Train to Naples Airport, fly to Amsterdam Airport Schiphol, train

    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Amsterdam Airport Schiphol (AMS)plane plane NAP - AMS
    3. Take the train from Schiphol Airport Train Station to Brussel-Zuidtrain train
    9h 12m
    €118–329

  10. Bus via Bologna

    1. Take the bus from Isernia to Bologna Centralebus bus 433
    2. Take the bus from Bologna to Brussels-North Stationbus bus
    28h 5m

  11. Drive, car train

    1. Drive from Isernia to Villach Hbfcar car
    2. Take the cartrain from Villach Hbf to Fuldacartrain train
    3. Drive from Fulda to Brusselscar car
    23h 27m
    €300–426

Fiumicino International Airport (FCO) to Brussels Airport (BRU) flights

Calendar61Weekly Planes
Duration2h 39mAverage Duration
Ticket€42Cheapest Price
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Comparing Your Travel Options

Map of how to get from Isernia to Brussels.ExpandLaunch map view
  • Distance: 1,403.3 km
  • Duration: 7h 31m

What companies run services between Isernia, Italy and Brussels, Belgium?

You can take a train from Isernia to Brussel-Zuid / Bruxelles-Midi via Roma Termini, Milano Centrale, Paris Gare de Lyon, and Paris Nord in around 15h 27m. Alternatively, you can take a bus from Isernia to Bruxelles - Rue du Progrès via Casello - A1 Ingresso Caianello in around 22h 42m.

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