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How to get fromIsernia to Brusselsby train, plane, train (Trenitalia, TGV, Eurostar), bus, car, or car train

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There are 11 ways to get from Isernia to Brussels by train, plane, train (Trenitalia, TGV, Eurostar), bus, car, or car train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Naples Airport, fly to Brussels Airport

    best
    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Brussels Airport (BRU)plane plane NAP - BRU
    7h 11m
    €80–217

  2. Bus to Abruzzo Airport, fly to Brussels South Charleroi Airport, train

    cheapest
    1. Take the bus from Isernia to Pescarabus bus
    2. Fly from Abruzzo Airport (PSR) to Brussels South Charleroi Airport (CRL)plane plane PSR - CRL
    3. Take the train from Charleroi-Central to Bruxelles-Centraltrain train
    10h 3m
    €60–294

  3. Train

    1. Take the train from Isernia to Roma Terminitrain train Re
    2. Take the train from Roma Termini to Torino Porta Susatrain train Fr
    3. Take the train from Torino Porta Susa to Paris Gare De Lyontrain train Tgv
    4. Take the train from Paris Nord to Brussel-Zuid / Bruxelles-Miditrain train
    15h 46m
    €254–630

  4. Bus

    1. Take the bus from Isernia to Casello - A1 Ingresso Caianellobus bus 6
    2. Take the bus from Casello - A1 Ingresso Caianello to Bruxelles - Rue du Progrèsbus bus
    22h 42m

  5. Drive 1,580.2 km

    1. Drive from Isernia to Brusselscar car 1,580.2 km
    16h 10m
    €246–355

  6. Train to Fiumicino International Airport, fly to Brussels Airport

    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Brussels Airport (BRU)plane plane FCO - BRU
    7h 29m
    €69–230

  7. Train to Naples Airport, fly to Brussels South Charleroi Airport, train

    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Brussels South Charleroi Airport (CRL)plane plane NAP - CRL
    3. Take the train from Charleroi-Central to Bruxelles-Centraltrain train
    8h 30m
    €75–285

  8. Train to Fiumicino International Airport, fly to Brussels South Charleroi Airport, train

    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Brussels South Charleroi Airport (CRL)plane plane FCO - CRL
    3. Take the train from Charleroi-Central to Bruxelles-Centraltrain train
    8h 57m
    €89–248

  9. Train to Fiumicino International Airport, fly to Eindhoven Airport, train

    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Eindhoven Airport (EIN)plane plane FCO - EIN
    3. Take the train from Eindhoven Centraal to Bredatrain train
    4. Take the train from Breda to Bruxelles-Centraltrain train
    10h 24m
    €111–345

  10. Bus via Bologna

    1. Take the bus from Isernia to Bologna Centralebus bus 433
    2. Take the bus from Bologna to Brussels-North Stationbus bus
    28h

  11. Drive, car train

    1. Drive from Isernia to Kufsteincar car
    2. Take the cartrain from Kufstein to Kassel-Wilhelmshöhecartrain train
    3. Drive from Kassel-Wilhelmshöhe to Brusselscar car
    19h 59m
    €311–441

Isernia to Brussels by train

Calendar70Weekly Trains
Duration15h 46mAverage Duration
Ticket€254Cheapest Price
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Questions & Answers

Map of how to get from Isernia to Brussels.ExpandLaunch map view
  • Distance: 1,475.4 km
  • Duration: 7h 11m

What companies run services between Isernia, Italy and Brussels, Belgium?

You can take a train from Isernia to Brussel-Zuid / Bruxelles-Midi via Roma Termini, Torino Porta Susa, Paris Gare de Lyon, and Paris Nord in around 15h 46m. Alternatively, you can take a bus from Isernia to Bruxelles - Rue du Progrès via Casello - A1 Ingresso Caianello in around 22h 42m.

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