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How to get fromIsernia to Florenceby train (Trenitalia), bus, car, train, or plane

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There are 9 ways to get from Isernia to Florence by train (Trenitalia), bus, car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Trenitalia)

    best
    1. Take the train from Isernia to Roma Terminitrain train Re
    2. Take the train from Roma Termini to Firenze S.M.N.train train Fr
    4h 13m
    €51–116

  2. Bus via Rome

    cheapest
    1. Take the bus from Isernia to Roma, Autostazione Tiburtinabus bus Campobasso / ...
    2. Take the bus from Roma, Autostazione Tiburtina to Florence Villa Constanza Bus Stationbus bus 510 / ...
    5h 56m
    €26–61

  3. Drive  427.8 km

    1. Drive from Isernia to Florencecar car 427.8 km
    4h 12m
    €68–98

  4. Train to Fiumicino International Airport, fly to Florence Peretola Airport

    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Florence Peretola Airport (FLR)plane plane FCO - FLR
    5h 17m
    €88–245

  5. Train via Firenze Santa Maria Novella

    1. Take the train from Isernia to Roma Terminitrain train Re
    2. Take the train from Roma Termini to Firenze Santa Maria Novellatrain train 8900 / ...
    4h 13m
    €53–101

  6. Train #2 (Trenitalia)

    1. Take the train from Isernia to Cassinotrain train Re
    2. Take the train from Cassino to Firenze S.M.N.train train Fr
    4h 49m
    €61–130

  7. Bus

    1. Take the bus from Isernia to Florence Villa Constanza Bus Stationbus bus 433
    9h 55m
    €45–80

  8. Train to Naples Airport, fly to Florence Peretola Airport

    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Florence Peretola Airport (FLR)plane plane NAP - FLR
    6h 58m
    €95–264

  9. Train to Fiumicino International Airport, fly to Bologna Guglielmo Marconi Airport, train

    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FCO - BLQ
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train
    5h 58m
    €81–250

Isernia to Florence by train (Trenitalia)

Calendar70Weekly Trains
Duration4h 13mAverage Duration
Ticket€51Cheapest Price
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Questions & Answers

Map of how to get from Isernia to Florence.ExpandLaunch map view
  • Distance: 446.8 km
  • Duration: 4h 13m

What companies run services between Isernia, Italy and Florence, Italy?

You can take a train from Isernia to Firenze S.M.N. via Roma Termini in around 4h 13m. Alternatively, you can take a bus from Isernia to Florence Villa Constanza Bus Station via Roma, Autostazione Tiburtina in around 5h 56m.

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