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How to get fromIsernia to Milanby train (Trenitalia), bus, car, train, or plane

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There are 10 ways to get from Isernia to Milan by train (Trenitalia), bus, car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Isernia to Roma Terminitrain train Re
    2. Take the train from Roma Termini to Milano Centraletrain train Fr / ...
    6h 24m
    €87–170

  2. Train to Naples Airport, fly to Milano Malpensa Airport, train

    cheapest
    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Milano Malpensa Airport (MXP)plane plane NAP - MXP
    3. Take the train from Malpensa Aeroporto T1 to Milano Porta Garibalditrain train
    6h 5m
    €34–175

  3. Bus

    1. Take the bus from Isernia to Termoli Terminal Busbus bus Cb 014
    2. Take the bus from Termoli Autostazione to Milano, San Donato M3bus bus Vieste
    10h 25m
    €56–98

  4. Drive  711.7 km

    1. Drive from Isernia to Milancar car 711.7 km
    7h 8m
    €116–167

  5. Train to Naples Airport, fly to Milan Linate Airport

    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Milan Linate Airport (LIN)plane plane NAP - LIN
    5h 6m
    €69–202

  6. Bus via Florence

    1. Take the bus from Isernia to Florence Villa Constanza Bus Stationbus bus 433
    2. Take the bus from Florence Villa Constanza Bus Station to Milano, San Donato M3bus bus N528 / ...
    14h 25m
    €68–122

  7. Train to Fiumicino International Airport, fly to Milan Linate Airport

    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Milan Linate Airport (LIN)plane plane FCO - LIN
    5h 30m
    €81–219

  8. Train to Naples Airport, fly to Il Caravaggio International Airport, bus

    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Il Caravaggio International Airport (BGY)plane plane NAP - BGY
    3. Take the bus from Milan Bergamo Orio al Serio Airport to Piazza Luigi di Savoiabus bus
    5h 55m
    €63–262

  9. Bus, bus to Abruzzo Airport, fly to Il Caravaggio International Airport

    1. Take the bus from Isernia to San Salvo Marinabus bus
    2. Take the bus from San Salvo Marina to Pescara Airportbus bus
    3. Fly from Abruzzo Airport (PSR) to Il Caravaggio International Airport (BGY)plane plane PSR - BGY
    4. Take the bus from Milan Bergamo Orio al Serio Airport to Piazza Luigi di Savoiabus bus
    6h 48m
    €47–284

  10. Bus, bus to Abruzzo Airport, fly to Milano Malpensa Airport, train

    1. Take the bus from Isernia to San Salvo Marinabus bus
    2. Take the bus from San Salvo Marina to Pescara Airportbus bus
    3. Fly from Abruzzo Airport (PSR) to Milano Malpensa Airport (MXP)plane plane PSR - MXP
    4. Take the train from Malpensa Aeroporto T1 to Milano Porta Garibalditrain train
    7h 3m
    €36–197

Isernia to Milan by train

Calendar35Weekly Trains
Duration6h 24mAverage Duration
Ticket€87Cheapest Price
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Comparing Your Travel Options

Map of how to get from Isernia to Milan.ExpandLaunch map view
  • Distance: 751.1 km
  • Duration: 6h 24m

What companies run services between Isernia, Italy and Milan, Italy?

You can take a train from Isernia to Milano Centrale via Roma Termini in around 6h 24m. Alternatively, you can take a bus from Isernia to Milano, San Donato M3 via Termoli Autostazione in around 10h 25m.

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