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How to get fromIsernia to Sicilyby train, plane, car, ferry, bus, or train (Trenitalia)

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There are 12 ways to get from Isernia to Sicily by train, plane, car, ferry, bus, or train (Trenitalia)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Naples Airport, fly to Catania–Fontanarossa Airport

    best
    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Catania–Fontanarossa Airport (CTA)plane plane NAP - CTA
    4h 54m
    €41–193

  2. Train to Naples Airport, fly to Palermo Airport

    cheapest
    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Palermo Airport (PMO)plane plane NAP - PMO
    5h 29m
    €36–204

  3. Drive, ferry

    1. Drive from Isernia to Naples Beverellocar car
    2. Take the ferry from Naples Beverello to Port of Palermoferry ferry
    9h 9m
    €49–97

  4. Bus via Caserta

    1. Take the bus from Isernia to Caserta Terminal Busbus bus 433
    2. Take the bus from Caserta pzza Garibaldi to Palermo Terminal Busbus bus Autoservizi Salemi S201
    12h 31m
    €39–58

  5. Train (Trenitalia)

    1. Take the train from Isernia to Napoli Afragolatrain train Re
    2. Take the train from Napoli Afragola to Palermo Centraletrain train Ic
    12h 52m
    €85–151

  6. Train to Fiumicino International Airport, fly to Catania–Fontanarossa Airport

    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Catania–Fontanarossa Airport (CTA)plane plane FCO - CTA
    5h 43m
    €51–150

  7. Train to Fiumicino International Airport, fly to Palermo Airport

    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Palermo Airport (PMO)plane plane FCO - PMO
    6h 13m
    €46–161

  8. Train to Fiumicino International Airport, fly to Vincenzo Magliocco Airport

    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Vincenzo Magliocco Airport (CIY)plane plane FCO - CIY
    5h 37m
    €81–372

  9. Bus, bus to Abruzzo Airport, fly to Catania–Fontanarossa Airport

    1. Take the bus from Isernia to San Salvo Marinabus bus
    2. Take the bus from San Salvo Marina to Pescara Airportbus bus
    3. Fly from Abruzzo Airport (PSR) to Catania–Fontanarossa Airport (CTA)plane plane PSR - CTA
    6h 17m
    €46–205

  10. Train, ferry

    1. Take the train from Isernia to Napoli Centraletrain train Re
    2. Take the ferry from Naples Beverello to Port of Palermoferry ferry
    11h 19m
    €49–97

  11. Train via Naples (Trenitalia)

    1. Take the train from Isernia to Napoli Centraletrain train Re
    2. Take the train from Napoli Centrale to Palermo Centraletrain train Ic
    12h 53m
    €87–153

  12. Bus

    1. Take the bus from Isernia to Caserta - Casagiovebus bus 558
    2. Take the bus from Caserta - Casagiove to Palermobus bus N592
    14h 21m
    €79–122

Isernia to Sicily by bus

Calendar7Weekly Buses
Duration12h 31mAverage Duration
Ticket€39Cheapest Price
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Comparing Your Travel Options

Map of how to get from Isernia to Sicily.ExpandLaunch map view
  • Distance: 506.6 km
  • Duration: 4h 54m

What companies run services between Isernia, Italy and Sicily, Italy?

You can take a bus from Isernia to Piazza Boiardo via Caserta Terminal Bus, Caserta pzza Garibaldi, Palermo Terminal Bus, and Stazione Centrale Pensilina Esterna in around 12h 31m. Alternatively, you can take a train from Isernia to Palermo Notarbartolo via Napoli Afragola and Palermo Centrale in around 12h 52m.

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